Modified Nucleosides
3'-beta-C-Ethynylcytidine
Quick view. A cytidine nucleoside bearing a 3'-C-ethynyl substituent and assigned beta-D-ribofuranosyl stereochemistry, CAS 180300-43-0. CAS 180300-43-0. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-beta-C-Ethynylcytidine is classified as modified nucleosides (Formula C11H13N3O5; molecular weight 267.24).
3'-beta-C-Ethynylcytidine is useful as a bioorthogonal handle for post-synthetic conjugation to fluorophores, affinity tags, surfaces, peptides or other functional payloads.
For 3'-beta-C-Ethynylcytidine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 3'-C-Ethynylcytidine
- Ethynylcytidine
- ECyd
- TAS-106
- 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine
Useful catalog search terms
- CAS 180300-43-0
- C11H13N3O5
- JFIWEPHGRUDAJN-DYUFWOLASA-N
Physicochemical data
| Nucleoside scaffold | Cytidine |
|---|---|
| Sugar modification | 3'-C-Ethynyl |
| Sugar stereochemistry | Assigned beta-D-ribofuranosyl configuration |
| InChI | InChI=1S/C11H13N3O5/c1-2-11(18)6(5-15)19-9(8(11)16)14-4-3-7(12)13-10(14)17/h1,3-4,6,8-9,15-16,18H,5H2,(H2,12,13,17)/t6-,8+,9-,11-/m1/s1 |
| InChIKey | JFIWEPHGRUDAJN-DYUFWOLASA-N |
| SMILES | C#C[C@]1([C@H](O[C@H]([C@@H]1O)N2C=CC(=NC2=O)N)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 3'-beta-C-Ethynylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-beta-C-Ethynylcytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0291 and CAS 180300-43-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact BX Lab product, supplied form, lot specification, availability or performance.
Technology platforms
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