Modified Nucleosides
3'-beta-C-Ethynyluridine
Quick view. We supply 3'-beta-C-Ethynyluridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 180300-49-6. Catalog target purity: Specification on request.
Product profile
3'-beta-C-Ethynyluridine is classified as nucleoside or protected nucleoside intermediate (Formula C11H12N2O6; molecular weight 268.22).
3'-beta-C-Ethynyluridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-beta-C-Ethynyluridine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 1-(3-C-Ethynylribopentofuranosyl)uracil
- 3’-β-C-Ethynyluridine
- Uridine, 3'-C-ethynyl-
Useful catalog search terms
- CAS 180300-49-6
- Nucleoside or protected nucleoside intermediate
- alkyne click handle
- Modified Nucleosides
Physicochemical data
| Key chemistry motifs | alkyne click handle |
|---|---|
| InChI | InChI=1S/C11H12N2O6/c1-2-11(18)6(5-14)19-9(8(11)16)13-4-3-7(15)12-10(13)17/h,3-4,6,8-9,14,16,18H,5H2,(H,12,15,17)/t6-,8+,9-,11-/m1/s |
| InChIKey | KNGMLOFYXFWJLZ-DYUFWOLASA-N |
| SMILES | C#C[C@]1([C@H](O[C@H]([C@@H]1O)N2C=CC(=O)NC2=O)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 3'-beta-C-Ethynyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-beta-C-Ethynyluridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0292 and CAS 180300-49-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 3'-beta-C-Ethynyluridine or the named structural feature represented by this product.