Halogenated Nucleosides
3'-Deoxy-3',5-difluorocytidine
Quick view. A cytidine derivative bearing fluorine at sugar C3' and base C5, identified by CAS 661470-65-1. CAS 661470-65-1. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-Deoxy-3',5-difluorocytidine is classified as halogenated nucleosides (Formula C9H11F2N3O4; molecular weight 263.20).
3'-Deoxy-3',5-difluorocytidine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 3'-Deoxy-3',5-difluorocytidine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 3'-Deoxy-3'-fluoro-5-fluorocytidine
Useful catalog search terms
- CAS 661470-65-1
Physicochemical data
| Nucleobase | Cytosine (pyrimidine) |
|---|---|
| Modifications | 3'-Deoxy-3'-fluoro and 5-fluoro |
| Isomeric SMILES | F[C@H]1[C@@H](O)[C@H](N2C=C(F)C(N)=NC2=O)O[C@@H]1CO |
| PubChem CID | 154706402 |
| InChIKey | KHGOGZGLQQVORD-UAKXSSHOSA-N |
| InChI | InChI=1S/C9H11F2N3O4/c10-3-1-14(9(17)13-7(3)12)8-6(16)5(11)4(2-15)18-8/h1,4-6,8,15-16H,2H2,(H2,12,13,17)/t4-,5-,6-,8-/m1/s1 |
| SMILES | C1=C(C(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)F)O)N)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3'-Deoxy-3',5-difluorocytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-Deoxy-3',5-difluorocytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0247 and CAS 661470-65-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.