Modified Nucleosides
3'-O-(2-Methoxyethyl)guanosine
Quick view. Guanosine derivative bearing a 3'-O-(2-methoxyethyl) substituent, with free 2'- and 5'-hydroxyl groups. CAS 256224-03-0. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-O-(2-Methoxyethyl)guanosine is classified as modified nucleosides (Formula C13H19N5O6; molecular weight 341.32 g/mol).
3'-O-(2-Methoxyethyl)guanosine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 3'-O-(2-Methoxyethyl)guanosine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 3'-O-MOE-guanosine
Useful catalog search terms
- 256224-03-0
Physicochemical data
| Systematic name | 2-amino-9-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-(2-methoxyethoxy)oxolan-2-yl]-1H-purin-6-one |
|---|---|
| Chemical form | Neutral 3'-O-MOE-modified guanosine |
| Structural scope | 3'-O-(2-methoxyethyl) substitution with free 2'- and 5'-hydroxyl groups |
| Stereochemical scope | Four defined ribose stereocenters |
| InChIKey | BPFOZTYDUWLNNN-WOUKDFQISA-N |
| SMILES | COCCO[C@@H]1[C@H](O[C@H]([C@@H]1O)N2C=NC3=C2N=C(NC3=O)N)CO |
| InChI | InChI=1S/C13H19N5O6/c1-22-2-3-23-9-6(4-19)24-12(8(9)20)18-5-15-7-10(18)16-13(14)17-11(7)21/h5-6,8-9,12,19-20H,2-4H2,1H3,(H3,14,16,17,21)/t6-,8-,9-,12-/m1/s1 |
| PubChem CID | 157419388 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-(2-Methoxyethyl)guanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-(2-Methoxyethyl)guanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0794 and CAS 256224-03-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.