Reverse Phosphoramidites
3'-O-DMTr-2'-O-(2-methoxyethyl)-5-methyluridine-5'-O-CED phosphoramidite
Quick view. A 2'-O-MOE 5-methyluridine reverse phosphoramidite with 3'-O-DMTr protection and a 5'-O cyanoethyl diisopropyl phosphoramidite group. CAS 1345715-43-6. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-O-DMTr-2'-O-(2-methoxyethyl)-5-methyluridine-5'-O-CED phosphoramidite is classified as reverse phosphoramidites (Formula C43H55N4O10P; molecular weight 818.90 g/mol).
3'-O-DMTr-2'-O-(2-methoxyethyl)-5-methyluridine-5'-O-CED phosphoramidite — Reverse-direction oligonucleotide synthesis
For 3'-O-DMTr-2'-O-(2-methoxyethyl)-5-methyluridine-5'-O-CED phosphoramidite, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- Rev 2'-O-MOE-5MeU-5'-amidite
- 3'-O-DMTr-2'-O-MOE-5MeU-5'-CE-Phosphoramidite
Useful catalog search terms
- 1345715-43-6
- YXJWAPDGJHYLNH-KZQAAKLLSA-N
Physicochemical data
| PubChem CID | 167312644 |
|---|---|
| IUPAC name | 3-[[(2R,3R,4R,5R)-3-[bis(4-methoxyphenyl)-phenylmethoxy]-4-(2-methoxyethoxy)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile |
| InChIKey | YXJWAPDGJHYLNH-KZQAAKLLSA-N |
| InChI | InChI=1S/C43H55N4O10P/c1-29(2)47(30(3)4)58(54-24-12-23-44)55-28-37-38(39(53-26-25-50-6)41(56-37)46-27-31(5)40(48)45-42(46)49)57-43(32-13-10-9-11-14-32,33-15-19-35(51-7)20-16-33)34-17-21-36(52-8)22-18-34/h9-11,13-22,27,29-30,37-39,41H,12,24-26,28H2,1-8H3,(H,45,48,49)/t37-,38-,39-,41-,58?/m1/s1 |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(N(C(C)C)C(C)C)OCCC#N)OC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OCCOC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-DMTr-2'-O-(2-methoxyethyl)-5-methyluridine-5'-O-CED phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-DMTr-2'-O-(2-methoxyethyl)-5-methyluridine-5'-O-CED phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-RP-0030 and CAS 1345715-43-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.