3'-O-Me Nucleosides
3'-O-Methyladenosine
Quick view. An adenosine nucleoside bearing a methyl ether at the ribose 3'-oxygen for nucleoside and oligonucleotide chemistry research. CAS 10300-22-8. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-O-Methyladenosine is classified as 3'-o-me nucleosides (Formula C11H15N5O4; molecular weight 281.27).
3'-O-Methyladenosine — Modified nucleoside building block for nucleoside and oligonucleotide chemistry research.
For 3'-O-Methyladenosine, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- 3'-O-Me-rA
- 3'-OMe-A
- 3'-O-Methyl-D-adenosine
Useful catalog search terms
- 10300-22-8
Physicochemical data
| MDL number | MFCD00057003 |
|---|---|
| Sugar modification | 3'-O-methyl |
| InChI | InChI=1S/C11H15N5O4/c1-19-8-5(2-17)20-11(7(8)18)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1 |
| InChIKey | RYAFZRROCNNRFK-IOSLPCCCSA-N |
| SMILES | CO[C@@H]1[C@H](O[C@H]([C@@H]1O)N2C=NC3=C(N=CN=C32)N)CO |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 3'-O-Methyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-Methyladenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-3OMN-0001 and CAS 10300-22-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 3'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.