3'-O-Me Nucleosides
3'-O-Methylguanosine
Quick view. 3'-O-Methylguanosine is a ribose-methylated guanosine derivative for research-use modified-nucleoside chemistry. CAS 10300-27-3. Catalog target purity: ≥98%. Availability: Inquiry only; contact BX Lab to confirm current availability.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
3'-O-Methylguanosine is classified as 3'-o-methyl ribonucleoside (Formula C11H15N5O5; molecular weight 297.27).
3'-O-Methylguanosine — 3'-O-methylated guanosine for research-use modified-nucleoside chemistry.
For 3'-O-Methylguanosine, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- 3'-O-Me-rG
- 3'-OMe-G
- Guanosine, 3'-O-methyl-
Useful catalog search terms
- CAS 10300-27-3
Physicochemical data
| PubChem CID | 135742509 |
|---|---|
| InChIKey | UYARPHAXAJAZLU-KQYNXXCUSA-N |
| Modification | Methyl ether at the ribose 3'-oxygen |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 3'-O-Methylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-Methylguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0157 and CAS 10300-27-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 3'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.