Modified Nucleosides
3'-O-tert-Butyldimethylsilyl-4'-C-hydroxymethylthymidine
Quick view. A 4'-C-hydroxymethylthymidine derivative protected as its 3'-O-tert-butyldimethylsilyl ether, CAS 139887-99-3. CAS 139887-99-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-O-tert-Butyldimethylsilyl-4'-C-hydroxymethylthymidine is classified as modified nucleosides (Formula C17H30N2O6Si; molecular weight 386.52).
3'-O-tert-Butyldimethylsilyl-4'-C-hydroxymethylthymidine is associated with cytosine-containing building blocks or substrates for C-position incorporation and analytical comparison.
For 3'-O-tert-Butyldimethylsilyl-4'-C-hydroxymethylthymidine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 3'-O-t-Butyldimethylsilyl-4'-C-hydroxymethylthymidine
- 3'-O-TBDMS-4'-C-hydroxymethylthymidine
Useful catalog search terms
- CAS 139887-99-3
Physicochemical data
| Systematic name | 1-[(2R,4S)-4-[(tert-butyldimethylsilyl)oxy]-5,5-bis(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione |
|---|---|
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H](C(O2)(CO)CO)O[Si](C)(C)C(C)(C)C |
| Sugar substitution | 4'-C-Hydroxymethyl |
| Hydroxyl protection | 3'-O-TBDMS |
| Free hydroxymethyl groups | Original 5' group and added 4'-C substituent |
| Product form | Protected modified nucleoside (not phosphoramidite) |
| PubChem CID | 11728775 |
| InChIKey | FJHHUZIOCDGZAK-QWHCGFSZSA-N |
| InChI | InChI=1S/C17H30N2O6Si/c1-11-8-19(15(23)18-14(11)22)13-7-12(17(9-20,10-21)24-13)25-26(5,6)16(2,3)4/h8,12-13,20-21H,7,9-10H2,1-6H3,(H,18,22,23)/t12-,13+/m0/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Frequently asked questions
Can the package size for 3'-O-tert-Butyldimethylsilyl-4'-C-hydroxymethylthymidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0242 and CAS 139887-99-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
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