Protected Nucleosides
3'-O-TBDMS-thymidine
Quick view. A thymidine building block bearing a 3'-O-TBDMS protecting group and a free 5'-hydroxyl group. CAS 40733-27-5. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-O-TBDMS-thymidine is classified as protected nucleosides (Formula C16H28N2O5Si; molecular weight 356.49).
3'-O-TBDMS-thymidine — Identity-defined 3'-O-protected thymidine building block for research workflows involving nucleoside, nucleotide, and oligonucleotide chemistry.
For 3'-O-TBDMS-thymidine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 3'-O-TBDMS-2'-dT
- 3'-O-tert-Butyldimethylsilylthymidine
- Thymidine 3'-O-TBDMS
Useful catalog search terms
- CAS 40733-27-5
Physicochemical data
| InChIKey | QAPSNMNOIOSXSQ-YNEHKIRRSA-N |
|---|---|
| Nucleoside | Thymidine (2'-deoxythymidine) |
| Sugar protection | 3'-O-TBDMS |
| Free hydroxyl group | 5' |
| InChI | InChI=1S/C16H28N2O5Si/c1-10-8-18(15(21)17-14(10)20)13-7-11(12(9-19)22-13)23-24(5,6)16(2,3)4/h8,11-13,19H,7,9H2,1-6H3,(H,17,20,21)/t11-,12+,13+/m0/s1 |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O[Si](C)(C)C(C)(C)C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Frequently asked questions
Can the package size for 3'-O-TBDMS-thymidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0112 and CAS 40733-27-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.