Protected Nucleosides
3'-O-TBDMS-2'-dT
Quick view. We supply 3'-O-TBDMS-2'-dT as a silyl-protected ribonucleoside intermediate for RNA monomer and specialty nucleoside synthesis. CAS 40733-27-5. Catalog target purity: Specification on request.
Product profile
3'-O-TBDMS-2'-dT is classified as nucleoside or protected nucleoside intermediate (Formula C16H28N2O5Si; molecular weight 356.49).
3'-O-TBDMS-2'-dT can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-O-TBDMS-2'-dT, storage: 2-8°C. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- 3'-O-TBDMS-dT
- 3'-O-(TBDMS)THYMIDINE
- 3'-O-t-BulyldiMethylsilyl thyMidine
- 3'-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE
- 3'-O-(tert-ButyldiMethylsilyl)thyMidine
- 3'-O-tert-butyldiMethylsilyl-2'-deoxythyMidine
- Thymidine, 3'-O-[(1,1-dimethylethyl)dimethylsilyl]-
Useful catalog search terms
- CAS 40733-27-5
- Nucleoside or protected nucleoside intermediate
- TBDMS protection
- Protected Nucleosides
Physicochemical data
| Key chemistry motifs | TBDMS protection |
|---|---|
| Melting point | 93-94 °C |
| Density | 1.17±0.1 g/cm3(Predicted) |
| pKa | 9.55±0.10(Predicted) |
| Form | Solid |
| Color | White to off-white |
| InChI | InChI=1S/C16H28N2O5Si/c1-10-8-18(15(21)17-14(10)20)13-7-11(12(9-19)22-13)23-24(5,6)16(2,3)4/h8,11-13,19H,7,9H2,1-6H3,(H,17,20,21)/t11-,12+,13+/m0/s |
| InChIKey | QAPSNMNOIOSXSQ-YNEHKIRRSA-N |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O[Si](C)(C)C(C)(C)C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 3'-O-TBDMS-2'-dT be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0112 and CAS 40733-27-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.