Protected Nucleosides
3'-O-TBDMS-2'-F-dU
Quick view. 2'-Fluoro-2'-deoxyuridine bearing a 3'-O-TBDMS group with a free 5'-hydroxyl group. CAS 1445379-59-8. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-O-TBDMS-2'-F-dU is classified as protected nucleosides (Formula C15H25FN2O5Si; molecular weight 360.46).
3'-O-TBDMS-2'-F-dU is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 3'-O-TBDMS-2'-F-dU, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 3'-O-TBDMS-2'-fluoro-2'-deoxyuridine
- 2'-Deoxy-3'-O-TBDMS-2'-fluorouridine
Useful catalog search terms
- CAS 1445379-59-8
Physicochemical data
| Nucleoside | 2'-Fluoro-2'-deoxyuridine |
|---|---|
| Hydroxyl protection | 3'-O-TBDMS |
| Hydroxyl state | 5' hydroxyl group unprotected |
| SMILES | CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](O[C@H]([C@@H]1F)N2C=CC(=O)NC2=O)CO |
| InChI | InChI=1S/C15H25FN2O5Si/c1-15(2,3)24(4,5)23-12-9(8-19)22-13(11(12)16)18-7-6-10(20)17-14(18)21/h6-7,9,11-13,19H,8H2,1-5H3,(H,17,20,21)/t9-,11-,12-,13-/m1/s1 |
| InChIKey | KKWGVZHEXOEALO-OJAKKHQRSA-N |
| PubChem CID | 122706669 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3'-O-TBDMS-2'-F-dU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-TBDMS-2'-F-dU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0070 and CAS 1445379-59-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.