Coupling Activators
4,5-Dicyanoimidazole (DCI)
Quick view. An acetonitrile-soluble phosphoramidite activator commonly used as an alternative to 1H-tetrazole. CAS 1122-28-7. Catalog target purity: ≥97%.
Product profile
4,5-Dicyanoimidazole (DCI) is classified as phosphoramidite coupling activator (Formula C5H2N4; molecular weight 118.1).
4,5-Dicyanoimidazole (DCI) — Activation of nucleoside phosphoramidites during solid-phase DNA and RNA synthesis.
For 4,5-Dicyanoimidazole (DCI), reported solubility: Soluble in Acetonitrile: 1.8g/10ml, DMSO, Methanol. Storage: Inert atmosphere,Room Temperature.
Names and search terms
Confirmed or normalized name variants
- 1h-imidazole-4,5-dicarbonitrile
- 4,5-IMIDAZOLEDICARBONITRILE
- ACTIVATOR
- AURORA 15196
- DCI
- IMIDAZOLE-4,5-DICARBONITRILE
- 4,5-DICYANOIMIDAZOL
- Dci(4,5-Dicyanoimidazole)
Useful catalog search terms
- CAS 1122-28-7
- Phosphoramidite coupling activator
- Coupling Activators
- Stereopure PS Reagents & Activators (PSI-ψ / CMPT)
Physicochemical data
| Melting point | 168-175 °C(lit.) |
|---|---|
| Boiling point | 569.3±35.0 °C(Predicted) |
| Density | 0.791 g/mL at 25 °C |
| pKa | 5.01±0.10(Predicted) |
| Form | Crystalline Powder |
| Color | solid white |
| SMILES | C1NC(C#N)=C(C#N)N=1 |
| InChI | InChI=1S/C5H2N4/c6-1-4-5(2-7)9-3-8-4/h3H,(H,8,9) |
| InChIKey | XGDRLCRGKUCBQL-UHFFFAOYSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Coupling-rate and conversion comparisons against tetrazole-based activation systems.
Related products
N-(Cyanomethyl)pyrrolidinium Triflate (CMPT)
Stereopure PS Reagents & Activators (PSI-ψ / CMPT) · CAS: N/A
BX-PSR-0002N-Phenylimidazolium Triflate (PhIMT)
Stereopure PS Reagents & Activators (PSI-ψ / CMPT) · CAS: N/A
BX-PSR-0003Benzimidazolium Triflate (BIT)
Stereopure PS Reagents & Activators (PSI-ψ / CMPT) · CAS: N/A
BX-PSR-00041H-Tetrazole
Stereopure PS Reagents & Activators (PSI-ψ / CMPT) · CAS: 288-94-8
BX-CA-00365-Benzylthio-1H-tetrazole (BTT)
Coupling Activators · CAS: 21871-47-6
BX-CA-00375-Ethylthio-1H-tetrazole (ETT)
Coupling Activators · CAS: 89797-68-2
Frequently asked questions
Can the package size for 4,5-Dicyanoimidazole (DCI) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CA-0035 and CAS 1122-28-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Coupling Activators product family and its named chemistry.