Coupling Activators
5-Ethylthio-1H-tetrazole (ETT)
Quick view. We supply 5-Ethylthio-1H-tetrazole (ETT) as an efficient coupling activator for DNA, RNA and modified phosphoramidite synthesis. CAS 89797-68-2. Catalog target purity: Specification on request.
Product profile
5-Ethylthio-1H-tetrazole (ETT) is classified as phosphoramidite coupling activator (Formula C3H6N4S; molecular weight 130.17).
5-Ethylthio-1H-tetrazole (ETT) — Solid-Phase Synthesis of Symmetrical Dinucleoside Phosphodiesters: Explores the efficiency of 5-(Ethylthio)-1H-tetrazole in the solid-phase synthesis of dinucleoside phosphodiesters, underlining its significance in the streamlined production of biologically relevant molecules (Ahmadibeni et al., 2007). Synthesis, Deprotection, Analysis,…
For 5-Ethylthio-1H-tetrazole (ETT), reported solubility: soluble, clear, colorless. Storage: Store at 0-5°C.
Names and search terms
Confirmed or normalized name variants
- 5-ETHYLSULFANYL-1H-TETRAZOLE
- 5-(ETHYLTHIO)TETRAZOLE
- 5-(S-ETHYLMERCAPTO)-TETRAZOLE
- ACTIVATOR
- ACTIVATOR REAGENT
- ETT
- 5-(ethvlthio)-1h-tetrazole
- 5-EETHYLTHIO-1H-TETRAZOLE (ETT)
Useful catalog search terms
- CAS 89797-68-2
- Phosphoramidite coupling activator
- Coupling Activators
Physicochemical data
| Melting point | 72-80 °C(lit.) |
|---|---|
| Boiling point | 81-82 °C |
| Density | 0.786 g/mL at 25 °C |
| pKa | 3.89±0.10(Predicted) |
| Color | solid white |
| SMILES | N1=C(SCC)N=NN1 |
| InChI | InChI=1S/C3H6N4S/c1-2-8-3-4-6-7-5-3/h2H2,1H3,(H,4,5,6,7) |
| InChIKey | GONFBOIJNUKKST-UHFFFAOYSA-N |
| Form | buffered aqueous solution |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5-Ethylthio-1H-tetrazole (ETT) can be screened as an activator for DNA, RNA or modified phosphoramidite coupling.
- Typical studies compare coupling speed, conversion, solubility and acid-related side products across monomer sets.
- Process qualification should control concentration, water content, reagent age and synthesis-platform compatibility.
Related products
Frequently asked questions
Can the package size for 5-Ethylthio-1H-tetrazole (ETT) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CA-0037 and CAS 89797-68-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5-Ethylthio-1H-tetrazole (ETT) or the named structural feature represented by this product.