Modified Nucleosides
4',5'-Didehydro-2',5'-dideoxyuridine
Quick view. A uridine analogue with a 4',5'-unsaturated sugar and 2',5'-dideoxy substitution pattern while retaining the uracil base. CAS 58096-66-5. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
4',5'-Didehydro-2',5'-dideoxyuridine is classified as unsaturated dideoxy uridine nucleoside (Formula C9H10N2O4; molecular weight 210.19 g/mol).
4',5'-Didehydro-2',5'-dideoxyuridine can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 4',5'-Didehydro-2',5'-dideoxyuridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- Uridine, 4',5'-didehydro-2',5'-dideoxy-
- 1-[(2R,4S)-4-Hydroxy-5-methylideneoxolan-2-yl]pyrimidine-2,4(1H,3H)-dione
Useful catalog search terms
- 58096-66-5
- GWUGJFCGJLMLER-POYBYMJQSA-N
Physicochemical data
| InChIKey | GWUGJFCGJLMLER-POYBYMJQSA-N |
|---|---|
| InChI | InChI=1S/C9H10N2O4/c1-5-6(12)4-8(15-5)11-3-2-7(13)10-9(11)14/h2-3,6,8,12H,1,4H2,(H,10,13,14)/t6-,8+/m0/s1 |
| SMILES | C=C1[C@H](C[C@@H](O1)N2C=CC(=O)NC2=O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 4',5'-Didehydro-2',5'-dideoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 4',5'-Didehydro-2',5'-dideoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0598 and CAS 58096-66-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.