Amino-modified Nucleosides
4'-alpha-Azido-cytidine
Quick view. We supply 4'-alpha-Azido-cytidine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 478182-28-4. Catalog target purity: Specification on request.
Product profile
4'-alpha-Azido-cytidine is classified as nucleoside or protected nucleoside intermediate (Formula C9H12N6O5; molecular weight 284.23).
4'-alpha-Azido-cytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 4'-alpha-Azido-cytidine, reported solubility: DMSO: ≥ 50 mg/mL (175.91 mM). Storage: Store at -20°C.
Names and search terms
Confirmed or normalized name variants
- R-1479
- 4'-Azidocytidine
- 4'-C-azidocytidine
- Cytidine, 4'-C-azido-
- 4’-alpha-Azido-cytidine, Balpiravir, R-1479
Useful catalog search terms
- CAS 478182-28-4
- Nucleoside or protected nucleoside intermediate
- azide click handle
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | azide click handle; amine functionality |
|---|---|
| InChI | InChI=1S/C9H12N6O5/c10-4-1-2-15(8(19)12-4)7-5(17)6(18)9(3-16,20-7)13-14-11/h1-2,5-7,16-18H,3H2,(H2,10,12,19)/t5-,6+,7-,9-/m1/s |
| InChIKey | ODLGMSQBFONGNG-JVZYCSMKSA-N |
| SMILES | C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@](O2)(CO)N=[N+]=[N-])O)O |
| Form | Powder |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 4'-alpha-Azido-cytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
3'-NH₂-ddA
Amino-modified Nucleosides · CAS: 7403-25-0
BX-MN-00073'-NH₂-ddC
Amino-modified Nucleosides · CAS: 84472-90-2
BX-MN-00083'-NH₂-ddG
Amino-modified Nucleosides · CAS: 66323-49-7
BX-MN-00093'-NH₂-ddT
Amino-modified Nucleosides · CAS: 52450-18-7
BX-MN-01762-NH₂-rA
Amino-modified Nucleosides · CAS: 2096-10-8
BX-AMN-00026-Amino-4-methoxy-1-(2-deoxy-3,5-di-O-(p-toluoyl)--D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
Amino-modified Nucleosides · CAS: 100644-68-6
Frequently asked questions
Can the package size for 4'-alpha-Azido-cytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0213 and CAS 478182-28-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 4'-alpha-Azido-cytidine or the named structural feature represented by this product.