2'-O-Me Phosphoramidites
4'-O-[(Hydroxy(methoxy)phosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)
Quick view. A 2'-O-methyluridine CE phosphoramidite bearing a neutral C4'-O-CH2-P(=O)(OH)(OMe) monomethyl phosphonate substituent for oligonucleotide synthesis research. A public CAS number is not assigned for this exact form. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
![Chemical structure of 4'-O-[(Hydroxy(methoxy)phosphoryl)methyl]-2'-O-methyluridine-3'-CE-Phosphoramidite](/structures/ffd1032d9375f97e.jpg)
Product profile
4'-O-[(Hydroxy(methoxy)phosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) is classified as 2'-o-me phosphoramidites (Formula C20H34N4O10P2; molecular weight 552.46).
4'-O-[(Hydroxy(methoxy)phosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) — Structurally defined 2'-O-methyluridine phosphoramidite building block for solid-phase oligonucleotide synthesis research.
For 4'-O-[(Hydroxy(methoxy)phosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite), excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 4'-O-(Monomethyl phosphonatomethyl)-2'-O-Me-rU-3'-CE-Phosphoramidite
- 4'-O-CH2-phosphate monomethyl ester-2'-O-Me-rU-3'-CE-Phosphoramidite
Useful catalog search terms
- 4'-O-[(Hydroxy(methoxy)phosphoryl)methyl]-2'-O-methyluridine-3'-CE-Phosphoramidite
- C20H34N4O10P2
- C4'-O-CH2 monomethyl phosphonate
Physicochemical data
| CAS status | No public CAS assigned |
|---|---|
| Phosphonate linkage | C4'-O-CH2-P(=O)(OH)(OMe) |
| 2'-O modification | methyl |
| Molecular form | Neutral phosphonic acid monomethyl ester |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 4'-O-[(Hydroxy(methoxy)phosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
4'-O-[(Dimethoxyphosphoryl)methyl]-2'-O-methyluridine-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2197181-94-3
BX-2OMP-00175'-Deoxy-5'-[(dimethoxyphosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-0019Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2419895-65-9
BX-2OMP-0020Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-0021Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-00236'-O-DMTr-2'-O-Me-5'-Homo-A(Bz)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2750354-56-2
Frequently asked questions
Can the package size for 4'-O-[(Hydroxy(methoxy)phosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0016, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.