BX LAB PRODUCT CATEGORY

2'-O-Me Phosphoramidites

Quick view. 2′-O-methyl ribonucleoside phosphoramidites for nuclease-resistant RNA, siRNA and antisense oligonucleotide research. This category currently includes 54 products. 2'-O-Me Phosphoramidites products provide protected, sequence-addressable building blocks for solid-phase oligonucleotide synthesis and modified-sequence research.

Products54

Use scopeResearch use only

Pack sizeCustomized to requirements

SupportSelection and custom synthesis review

Category guide

Typical use

2'-O-Me Phosphoramidites products provide protected, sequence-addressable building blocks for solid-phase oligonucleotide synthesis and modified-sequence research.

How to select

Confirm base and sugar identity, protecting groups, stereochemistry, linker or label position, and compatibility with coupling and deprotection conditions.

How to qualify

Review identity, chromatographic purity, phosphorus-related quality attributes, water sensitivity and performance in a short test sequence.

Product-family considerations

Common advantages

Phosphoramidite chemistry is modular, automated and compatible with fast sequence iteration.
Modified sugar, base or linker motifs let researchers tune duplex stability, specificity, hydrophobicity, steric profile and downstream conjugation options.
Common ribose modifications can improve nuclease resistance and modulate RNA-like binding behavior.

Common limitations

Modified amidites can require adjusted coupling time, activator choice, deprotection conditions and analytical release methods.
Moisture sensitivity and storage history are important because degraded amidite can reduce coupling efficiency.

Category literature

These publications provide background for the 2'-O-Me Phosphoramidites product family. Individual product pages only show additional product- or feature-relevant references.

Selection checklist

Exact identity	Match the canonical name with a CAS number, structure, SMILES or drawing; confirm stereochemistry, protecting groups and salt form where applicable.
Specification	Define target purity, analytical method, water or residual-solvent concerns and any application-specific acceptance limits.
Workflow fit	Share the reaction, enzyme, sequence, solvent system, support or analytical method used to evaluate compatibility.
Supply need	Provide initial quantity, expected future scale, packaging preference, timeline and documentation requirements.

54 products

4'-O-CH2-phosphate methyl ester-2'-O-Me-rU-3'-CE-Phosphoramidite

≥95% · CAS: 2197181-94-3

BX-2OMP-0015 4'-O-CH₂-phosphate monomethyl ester-2'-O-Me-rU-3'-CE-Phosphoramidite

Specification on request · CAS: N/A

BX-2OMP-0016 5'-CH₂-phosphate methyl ester-2'-O-Me-U-3'-CE-Phosphoramidite

≥95% · CAS: N/A

BX-2OMP-0017 5'-POM-(E)-vinyl phosphonate-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'- CE-Phosphoramidite

Specification on request · CAS: N/A

BX-2OMP-0018 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite

≥95% · CAS: 2419895-65-9

BX-2OMP-0019 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite

Specification on request · CAS: N/A

BX-2OMP-0020 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite

Specification on request · CAS: N/A

BX-2OMP-0021 5'-POM-cyclopropyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite

Specification on request · CAS: N/A

BX-2OMP-0022 6'-O-DMTr-2'-O-Me-5'-Homo-A(Bz)-3'-CE-Phosphoramidite

≥95% · CAS: 2750354-56-2

BX-2OMP-0023 6'-O-DMTr-2'-O-Me-5'-Homo-U-3'-CE-Phosphoramidite

Specification on request · CAS: 2714382-62-2

BX-2OMP-0024 DMTr-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid methyl ester)-rA-3'-CE-Phosphoramidite

Specification on request · CAS: N/A

BX-2OMP-0025 DMTr-2'-O-Me-N2,N6-Diibu-2-amido-rA-3'-CE-Phosphoramidite

Specification on request · CAS: 160526-51-2

BX-2OMP-0026 DMTr-2'-O-Me-N2-iBu-N6-dmf- 2-amido-rA-3'-CE-Phosphoramidite

Specification on request · CAS: N/A

BX-2OMP-0027 DMTr-2'-O-Me-N6-Me-rA(Bz)-3'-CE-Phosphoramidite

≥98% · CAS: 2659239-32-2

BX-2OMP-0028 DMTr-2'-O-Me-PseudoU-3'-CE-Phosphoramidite

≥95% · CAS: 199737-09-2

BX-2OMP-0029 DMTr-2'-O-Me-rA(Bz)-3'-(D)-DPSE-Phosphoramidite

Specification on request · CAS: 1528733-91-6

BX-2OMP-0030 DMTr-2'-O-Me-rA(Bz)-3'-(D)-PSM-Phosphoramidite

Specification on request · CAS: 2379296-27-0

BX-2OMP-0031 DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-Phosphoramidite

≥95% · CAS: 2379296-17-8

BX-2OMP-0032 DMTr-2'-O-Me-rC(Ac)-3'-(L)-PSM-Phosphoramidite

Specification on request · CAS: N/A

BX-2OMP-0033 DMTr-2'-O-Me-rC(Bz)-3'-(L)-DPSE-Phosphoramidite

≥95% · CAS: N/A

BX-2OMP-0034 DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite

≥98% · CAS: 128219-77-2

BX-2OMP-0035 DMTr-2'-O-Me-rG(iBu)-3'-(D)-DPSE-Phosphoramidite

≥95% · CAS: 2227139-99-1

BX-2OMP-0036 DMTr-2'-O-Me-rG(iBu)-3'-(L)-DPSE-Phosphoramidite

≥95% · CAS: 2227139-95-7

BX-2OMP-0037 DMTr-2'-O-Me-rG(iBu)-3'-(L)-PSM-Phosphoramidite

Specification on request · CAS: N/A

BX-2OMP-0038 DMTr-2'-O-Me-rI-3'-CE-Phosphoramidite

≥96% · CAS: 128219-85-2

BX-2OMP-0039 DMTr-2'-O-Me-rU-3'-(D)-PSM-Phosphoramidite

Specification on request · CAS: N/A

BX-2OMP-0040 DMTr-2'-O-Me-rU-3'-(L)-PSM-Phosphoramidite

Specification on request · CAS: 2963598-67-4

BX-2OMP-0041 DMTr-R-5'-C-Me-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite

≥98% · CAS: 3055727-88-0

BX-2OMP-0042 DMTr-S-5-C-Me-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite

≥95% · CAS: 3060423-81-3

BX-2OMP-0043 DMTr-S-5-C-Me-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite

≥95% · CAS: 1883486-16-5

BX-2OMP-0044 DMTr-S-5-C-Me-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite

≥95% · CAS: N/A

BX-2OMP-0045 DMTr-S-5-C-Me-2'-O-Me-rU-3'-CE-Phosphoramidite

≥95% · CAS: 2747890-15-7

BX-2OMP-0046 Methacrylation-2'-O-Me-rU-3'-CE-Phosphoramidite

Specification on request · CAS: N/A

BX-2OMP-0047 2'-OMe-5-Me-C(Bz) Phosphoramidite

Specification on request · CAS: 166593-57-3

BX-2OMP-0055 2'-OMe-5-Me-U Phosphoramidite

Specification on request · CAS: 153631-20-0

BX-2OMP-0056 DMTr-2'-O-Me-rU-3'-(L)-DPSE-Phosphoramidite

Specification on request · CAS: 1528733-97-2

BX-2OMP-0065 DMTr-2'-O-Me-rA(Bz)-3'-(L)-DPSE-Phosphoramidite

Specification on request · CAS: 1528733-90-5

BX-2OMP-0066 DMTr-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid 2-cyanoethyl ester)-rA-3'-CE-Phosphoramidite

Specification on request · CAS: 1809205-58-0

BX-2OMP-0067 6'-O-DMTr-2'-O-Me-5'-Homo-C(Ac)-3'-CE-Phosphoramidite

Specification on request · CAS: 2714382-70-2

BX-2OMP-0068 6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-CE-Phosphoramidite

Specification on request · CAS: 2714383-00-1

BX-2OMP-0069 DMTr-2'-O-Me-rU-3'-(D)-DPSE-Phosphoramidite

Specification on request · CAS: 1528733-98-3

BX-2OMP-0070 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite

Specification on request · CAS: 2172373-55-4

BX-2OMP-0071 DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite

Specification on request · CAS: 110764-78-8

BX-2OMP-0072 DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite

Specification on request · CAS: 110782-31-5

BX-2OMP-0073 DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite

Specification on request · CAS: 199593-09-4

BX-2OMP-0074 DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite

Specification on request · CAS: 150780-67-9

BX-2OMP-0075 DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite

Specification on request · CAS: 110764-79-9

BX-2OMP-0076 5-methyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methyl-Uridine-3'-CE-Phosphoramidite

Specification on request · CAS: 168611-18-5

BX-2MEP-0001 2, 6-diamino(N2, N6-diPhenoxyacetyl)-5'-O-(4, 4'-Dimethoxytrityl)-2'-O-methyl-purine riboside-3'-cyanoethyl Phosphoramidite

Specification on request · CAS: N/A

BX-2MEP-0002 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-N6-methyladenosine 3'-CED phosphoramidite

Specification on request · CAS: 2348385-04-4

BX-2MEP-0003 2'-O-Me-2-thio-U-3'-phos phoramidite

Specification on request · CAS: 302918-84-9

BX-2MEP-0004 5'-O-(4, 4'-Dimethoxytrityl)-1'-urea-2'-O-methyl phosphoramidite

Specification on request · CAS: N/A

BX-2MEP-0005 O4-(p-tolyl pivalate)-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methyl-uridine-3'-cyanoethyl Phosphoramidite

Specification on request · CAS: N/A

BX-2MEP-0006 O6-(p-tolyl pivalate)-N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methyl-guanosine-3'-cyanoethyl Phosphoramidite

Specification on request · CAS: N/A

BX-2MEP-0007

Frequently asked questions

What are typical uses for 2'-O-Me Phosphoramidites?

2'-O-Me Phosphoramidites products provide protected, sequence-addressable building blocks for solid-phase oligonucleotide synthesis and modified-sequence research.

What should be confirmed before ordering 2'-O-Me Phosphoramidites?

Confirm base and sugar identity, protecting groups, stereochemistry, linker or label position, and compatibility with coupling and deprotection conditions.

Are custom quantities or related analogs available?

BX Lab reviews custom package sizes, catalog-adjacent analogs and research-use custom synthesis requests against the target structure, purity, scale and timeline.

Need help selecting a product?

Tell our scientists about your target chemistry, workflow, required purity and scale. We can help identify a catalog product, related analog or custom route.

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