2'-O-Me Phosphoramidites
5'-O-DMTr-2'-O-Me-N2,N6-bis(isobutyryl)-2-aminoadenosine-3'-CE-Phosphoramidite
Quick view. An N2,N6-bis(isobutyryl)-protected 2-aminoadenosine CE phosphoramidite bearing 5'-O-DMTr and 2'-O-methyl groups for oligonucleotide synthesis research. CAS 160526-51-2. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-DMTr-2'-O-Me-N2,N6-bis(isobutyryl)-2-aminoadenosine-3'-CE-Phosphoramidite is classified as 2'-o-me phosphoramidites (Formula C49H63N8O9P; molecular weight 939.06).
5'-O-DMTr-2'-O-Me-N2,N6-bis(isobutyryl)-2-aminoadenosine-3'-CE-Phosphoramidite — N2,N6-protected 2-aminoadenosine 2'-O-methyl phosphoramidite building block for oligonucleotide synthesis research.
For 5'-O-DMTr-2'-O-Me-N2,N6-bis(isobutyryl)-2-aminoadenosine-3'-CE-Phosphoramidite, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- DMTr-2'-O-Me-N2,N6-Diibu-2-amido-rA-3'-CE-Phosphoramidite
- Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-2-[(2-methyl-1-oxopropyl)amino]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
Useful catalog search terms
- CAS 160526-51-2
- C49H63N8O9P
- GBCWEEZHQVKVPU-FKYZNXHZSA-N
Physicochemical data
| InChIKey | GBCWEEZHQVKVPU-FKYZNXHZSA-N |
|---|---|
| Nucleobase protection | N2,N6-bis(isobutyryl)-2-aminoadenosine |
| Ribose modification | 2'-O-methyl |
| Coupling group | 3'-CE phosphoramidite |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-Me-N2,N6-bis(isobutyryl)-2-aminoadenosine-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-Me-N2,N6-bis(isobutyryl)-2-aminoadenosine-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0026 and CAS 160526-51-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.