2'-O-Me Phosphoramidites
5'-O-DMTr-2'-O-Me-N2-isobutyryl-N6-[(dimethylamino)methylene]-2-aminoadenosine-3'-CE-Phosphoramidite
Quick view. A protected 2-aminoadenosine CE phosphoramidite bearing N2-isobutyryl, N6-[(dimethylamino)methylene], 5'-O-DMTr and 2'-O-methyl groups for oligonucleotide synthesis research. A public CAS number is not assigned for this exact form. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
![Chemical structure of 5'-O-DMTr-2'-O-Me-N2-isobutyryl-N6-[(dimethylamino)methylene]-2-aminoadenosine-3'-CE-Phosphoramidite](/structures/ae0243df747ebfef.jpg)
Product profile
5'-O-DMTr-2'-O-Me-N2-isobutyryl-N6-[(dimethylamino)methylene]-2-aminoadenosine-3'-CE-Phosphoramidite is classified as 2'-o-me phosphoramidites.
5'-O-DMTr-2'-O-Me-N2-isobutyryl-N6-[(dimethylamino)methylene]-2-aminoadenosine-3'-CE-Phosphoramidite — Protected 2-aminoadenosine 2'-O-methyl phosphoramidite building block for oligonucleotide synthesis research.
For 5'-O-DMTr-2'-O-Me-N2-isobutyryl-N6-[(dimethylamino)methylene]-2-aminoadenosine-3'-CE-Phosphoramidite, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- DMTr-2'-O-Me-N2-iBu-N6-dmf-2-amido-rA-3'-CE-Phosphoramidite
- PA064
Physicochemical data
| Nucleobase protection | N2-isobutyryl and N6-[(dimethylamino)methylene] |
|---|---|
| Ribose modification | 2'-O-methyl |
| 5' protection | 5'-O-DMTr |
| Coupling group | 3'-CE phosphoramidite |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-Me-N2-isobutyryl-N6-[(dimethylamino)methylene]-2-aminoadenosine-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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BX-2OMP-0019Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite
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2'-O-Me Phosphoramidites · CAS: N/A
Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-Me-N2-isobutyryl-N6-[(dimethylamino)methylene]-2-aminoadenosine-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0027, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.