2'-O-Me Phosphoramidites
DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite
Quick view. DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite is a 2'-O-methyl uridine building block for research-use oligonucleotide synthesis. CAS 110764-79-9. Catalog target purity: 98.8%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite is classified as 2'-o-methyl uridine phosphoramidite (Formula C40H49N4O9P; molecular weight 760.80).
DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite — 2'-O-methyl uridine phosphoramidite building block for research-use oligonucleotide synthesis.
For DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-U Phosphoramidite
- DMT-2'-O-methyl-rU Phosphoramidite
- 5'-O-DMTr-2'-O-methyluridine-3'-CE Phosphoramidite
Useful catalog search terms
- 110764-79-9
- PubChem 10897989
- C40H49N4O9P
- Thermo Fisher 27-1825-87
- Areterna PA014
Physicochemical data
| Ribose modification | 2'-O-methyl |
|---|---|
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | UVUOJOLPNDCIHL-XKZJCBTISA-N |
| InChI | InChI=1S/C40H49N4O9P/c1-27(2)44(28(3)4)54(51-25-11-23-41)53-36-34(52-38(37(36)49-7)43-24-22-35(45)42-39(43)46)26-50-40(29-12-9-8-10-13-29,30-14-18-32(47-5)19-15-30)31-16-20-33(48-6)21-17-31/h8-10,12-22,24,27-28,34,36-38H,11,25-26H2,1-7H3,(H,42,45,46)/t34-,36-,37-,38-,54?/m1/s1 |
| SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3ccc(O)nc3=O)[C@H](OC)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-00175'-Deoxy-5'-[(dimethoxyphosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)
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BX-2OMP-0019Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite
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BX-2OMP-0020Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite
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BX-2OMP-0021Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0076 and CAS 110764-79-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.