2'-O-Me Phosphoramidites
DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite
Quick view. DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite is an N2-isobutyryl-protected 2'-O-methyl guanosine building block for research-use oligonucleotide synthesis. CAS 150780-67-9. Catalog target purity: ≥98.0%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite is classified as protected 2'-o-methyl guanosine phosphoramidite (Formula C45H56N7O9P; molecular weight 869.90).
DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite — N2-isobutyryl-protected 2'-O-methyl guanosine phosphoramidite building block for research-use oligonucleotide synthesis.
For DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-G(iBu) Phosphoramidite
- DMT-2'-O-methyl-rG(iBu) Phosphoramidite
- N2-Isobutyryl-5'-O-DMTr-2'-O-methylguanosine-3'-CE Phosphoramidite
Useful catalog search terms
- 150780-67-9
- PubChem 135587728
- C45H56N7O9P
- Areterna PA013
Physicochemical data
| Base protection | N2-isobutyryl |
|---|---|
| Ribose modification | 2'-O-methyl |
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | IRRDHRZUOZNWDJ-MLLDKZSOSA-N |
| InChI | InChI=1S/C45H56N7O9P/c1-28(2)41(53)49-44-48-40-37(42(54)50-44)47-27-51(40)43-39(57-9)38(61-62(59-25-13-24-46)52(29(3)4)30(5)6)36(60-43)26-58-45(31-14-11-10-12-15-31,32-16-20-34(55-7)21-17-32)33-18-22-35(56-8)23-19-33/h10-12,14-23,27-30,36,38-39,43H,13,25-26H2,1-9H3,(H2,48,49,50,53,54)/t36-,38-,39-,43-,62?/m1/s1 |
| SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(O)nc(NC(=O)C(C)C)nc43)[C@H](OC)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-2OMP-00175'-Deoxy-5'-[(dimethoxyphosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)
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BX-2OMP-0019Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite
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BX-2OMP-0020Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite
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BX-2OMP-0021Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
Frequently asked questions
Can the package size for DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0075 and CAS 150780-67-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.