2'-O-Me Phosphoramidites
5'-O-DMTr-5-methyl-2'-O-methyluridine-3'-CE phosphoramidite
Quick view. A protected 5-methyl-2'-O-methyluridine phosphoramidite bearing a 5'-DMTr group and a 3'-cyanoethyl N,N-diisopropylphosphoramidite group. CAS 153631-20-0. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-DMTr-5-methyl-2'-O-methyluridine-3'-CE phosphoramidite is classified as 2'-o-me phosphoramidites (Formula C41H51N4O9P; molecular weight 774.84).
5'-O-DMTr-5-methyl-2'-O-methyluridine-3'-CE phosphoramidite — Identity-defined protected 5-methyl-2'-O-methyluridine CE phosphoramidite for research workflows involving solid-phase oligonucleotide synthesis.
For 5'-O-DMTr-5-methyl-2'-O-methyluridine-3'-CE phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-5-Me-U phosphoramidite
- 2'-O-methyl-5-methyl-U CEP
- 5-Me-DMTr-2'-O-Me-U-CE phosphoramidite
- 5'-O-DMTr-2'-O-Me-5MeU-3'-CED phosphoramidite
Useful catalog search terms
- CAS 153631-20-0
Physicochemical data
| Nucleoside | 5-Methyl-2'-O-methyluridine |
|---|---|
| Sugar modification | 2'-O-Methyl |
| 5' protection | DMTr |
| Base modification | 5-Methyl |
| 3'-Coupling group | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
| PubChem CID | 10327870 |
| InChI | InChI=1S/C41H51N4O9P/c1-27(2)45(28(3)4)55(52-24-12-23-42)54-36-35(53-39(37(36)50-8)44-25-29(5)38(46)43-40(44)47)26-51-41(30-13-10-9-11-14-30,31-15-19-33(48-6)20-16-31)32-17-21-34(49-7)22-18-32/h9-11,13-22,25,27-28,35-37,39H,12,24,26H2,1-8H3,(H,43,46,47)/t35-,36-,37-,39-,55?/m1/s1 |
| InChIKey | GMJRPRHRYILEOK-VNZAIEIISA-N |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-5-methyl-2'-O-methyluridine-3'-CE phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
4'-O-[(Dimethoxyphosphoryl)methyl]-2'-O-methyluridine-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2197181-94-3
BX-2OMP-00164'-O-[(Hydroxy(methoxy)phosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-00175'-Deoxy-5'-[(dimethoxyphosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-0019Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2419895-65-9
BX-2OMP-0020Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-0021Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
Frequently asked questions
Can the package size for 5'-O-DMTr-5-methyl-2'-O-methyluridine-3'-CE phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0056 and CAS 153631-20-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.