2'-O-Me Phosphoramidites
5'-O-DMTr-5-methyl-2'-O-methyluridine-3'-CE phosphoramidite
Quick view. A protected 5-methyl-2'-O-methyluridine phosphoramidite bearing a 5'-DMTr group and a 3'-cyanoethyl N,N-diisopropylphosphoramidite group. CAS 153631-20-0. Catalog target purity: ≥98%. Availability: Inquiry only; contact BX Lab to confirm current availability.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
5'-O-DMTr-5-methyl-2'-O-methyluridine-3'-CE phosphoramidite is classified as 2'-o-me phosphoramidites (Formula C41H51N4O9P; molecular weight 774.84).
5'-O-DMTr-5-methyl-2'-O-methyluridine-3'-CE phosphoramidite — Identity-defined protected 5-methyl-2'-O-methyluridine CE phosphoramidite for research workflows involving solid-phase oligonucleotide synthesis.
For 5'-O-DMTr-5-methyl-2'-O-methyluridine-3'-CE phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-5-Me-U phosphoramidite
- 2'-O-methyl-5-methyl-U CEP
- 5-Me-DMTr-2'-O-Me-U-CE phosphoramidite
- 5'-O-DMTr-2'-O-Me-5MeU-3'-CED phosphoramidite
Useful catalog search terms
- CAS 153631-20-0
Physicochemical data
| Nucleoside | 5-Methyl-2'-O-methyluridine |
|---|---|
| Sugar modification | 2'-O-Methyl |
| 5'-Protecting group | DMTr |
| Base modification | 5-Methyl |
| 3'-Coupling group | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-5-methyl-2'-O-methyluridine-3'-CE phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
4'-O-[(Dimethoxyphosphoryl)methyl]-2'-O-methyluridine-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2197181-94-3
BX-2OMP-00164'-O-[(Hydroxy(methoxy)phosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-00175'-Deoxy-5'-[(dimethoxyphosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-0019Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: 2419895-65-9
BX-2OMP-0020Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
BX-2OMP-0021Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite
2'-O-Me Phosphoramidites · CAS: N/A
Frequently asked questions
Can the package size for 5'-O-DMTr-5-methyl-2'-O-methyluridine-3'-CE phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0056 and CAS 153631-20-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.