2'-O-Me Phosphoramidites
DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite
Quick view. A 5'-O-DMTr-protected, N2-dimethylformamidine-protected 2'-O-methyl guanosine CE phosphoramidite for oligonucleotide synthesis research. CAS 128219-77-2. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite is classified as 2'-o-me phosphoramidites (Formula C44H55N8O8P; molecular weight 854.93).
DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite — Protected 2'-O-methyl guanosine phosphoramidite building block for oligonucleotide synthesis research.
For DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-dmf-G-CE Phosphoramidite
- 2'-O-Methyl-N2-dimethylformamidine-5'-O-DMT-guanosine-3'-CE phosphoramidite
Useful catalog search terms
- CAS 128219-77-2
- ZGDBCILCTOHNAB-NANSYJOBSA-N
Physicochemical data
| InChIKey | ZGDBCILCTOHNAB-NANSYJOBSA-N |
|---|---|
| Nucleobase protection | N2-dimethylformamidine |
| Ribose modification | 2'-O-methyl |
| 5' protection | 5'-O-DMTr |
| Coupling group | 3'-CE phosphoramidite |
| Phosphorus stereochemistry | Unspecified |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0035 and CAS 128219-77-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.