2'-O-Me Phosphoramidites
6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-CE-Phosphoramidite
Quick view. 6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-CE-Phosphoramidite is an N2-isobutyryl-protected 2'-O-methyl-5'-homo-guanosine building block for research-use oligonucleotide synthesis. CAS 2714383-00-1. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-CE-Phosphoramidite is classified as protected 2'-o-methyl-5'-homo-guanosine phosphoramidite (Formula C46H58N7O9P; molecular weight 884.00).
6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-CE-Phosphoramidite — N2-isobutyryl-protected 2'-O-methyl-5'-homo-guanosine phosphoramidite building block for research-use oligonucleotide synthesis.
For 6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 6'-O-DMT-2'-O-Me-5'-Homo-G(iBu)-3'-CE-Phosphoramidite
- 6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-2-cyanoethyl phosphoramidite
Useful catalog search terms
- 2714383-00-1
- PubChem 178421347
- C46H58N7O9P
- Synthgene PA228
- 2'-O-Me Phosphoramidites
Physicochemical data
| Base protection | N2-isobutyryl |
|---|---|
| Ribose modification | 2'-O-methyl and 5'-homo |
| Synthesis format | 6'-O-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | XKHQAUXVNXCGCR-NOYBBXANSA-N |
| InChI | InChI=1S/C46H58N7O9P/c1-29(2)42(54)50-45-49-41-38(43(55)51-45)48-28-52(41)44-40(58-9)39(62-63(60-26-13-25-47)53(30(3)4)31(5)6)37(61-44)24-27-59-46(32-14-11-10-12-15-32,33-16-20-35(56-7)21-17-33)34-18-22-36(57-8)23-19-34/h10-12,14-23,28-31,37,39-40,44H,13,24,26-27H2,1-9H3,(H2,49,50,51,54,55)/t37-,39-,40-,44-,63?/m1/s1 |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CCOC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OC |
| PubChem CID | 178421347 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0069 and CAS 2714383-00-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.