Modified Nucleosides
4-thiouridine
Quick view. We supply 4-thiouridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 13957-31-8. Catalog target purity: ≥98%.
Product profile
4-thiouridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H12N2O5S; molecular weight 260.26).
4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases.
For 4-thiouridine, reported solubility: Soluble in water and methanol; confirm lot-specific concentration limits. Storage: −20 °C, protected from light.
Names and search terms
Confirmed or normalized name variants
- THIOURIDINE, 4-
- thiouridine
- 4-thiouridineapprox.
- 4-Thio-D-uridine
Useful catalog search terms
- CAS 13957-31-8
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| Melting point | 141–143 °C |
|---|---|
| SMILES | OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=S)NC1=O |
| InChIKey | ZLOIGESWDJYCTF-XVFCMESISA-N |
| InChI | InChI=1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s |
| Density | 1.72±0.1 g/cm3(Predicted) |
| pKa | 4.75±0.20(Predicted) |
| Form | crystalline |
| Color | light yellow |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 4-thiouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Related products
(S)-cEt-rA
Modified Nucleosides · CAS: 1197033-34-3
BX-OP-0069S-Adenosylmethionine (SAM)
Modified Nucleosides · CAS: 485-80-3
BX-MN-0185(R-/S-) 5-Carbamoylhydroxy methyluridine
Modified Nucleosides · CAS: N/A
BX-MN-0186(R-/S-)5-(1-Hydroxy)(methoxycarbonyl)methyl uridine
Modified Nucleosides · CAS: N/A
BX-MN-0187(R-/S-)5-Carboxyhydroxymethyl uridine
Modified Nucleosides · CAS: N/A
BX-MN-0719(R)-N-(2,3-dihydro-1H-indenyl)adenosine
Modified Nucleosides · CAS: 96392-15-3
Frequently asked questions
Can the package size for 4-thiouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0521 and CAS 13957-31-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.