Modified Nucleosides
4'-Thiouridine
Quick view. We supply 4'-Thiouridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 6741-73-7. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
4'-Thiouridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H12N2O5S; molecular weight 260.27).
4'-Thiouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 4'-Thiouridine, form: Solid.
Names and search terms
Confirmed or normalized name variants
- 1-(4-thio-β-D-ribofuranosyl)uracil
- 1-(4-thio-beta-D-ribofuranosyl)uracil
- 4’-Thiouridine, 1-(4-Thio-beta-D-ribofuranosyl)uracil
Useful catalog search terms
- CAS 6741-73-7
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| Melting point | 195-196 °C(Solv: chloroform (67-66-3); ethanol (64-17-5)) |
|---|---|
| Density | 1.687±0.06 g/cm3(Predicted) |
| pKa | 9.39±0.10(Predicted) |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 4'-Thiouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0631 and CAS 6741-73-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 4'-Thiouridine or the named structural feature represented by this product.
- Nucleotide resolution 4-thiouridine sequencing by SNU-Seq and sf4sU-Seq reveals the transcriptional responsiveness of an epigenetically primed human genome. (2026)
- Ultrafast Excited-State Dynamics and Two-Photon Near-Infrared Induced Photodynamic Therapy Performance of 5‑Phenylethynyl-4-thiouridine. (2026)
- RudS: bacterial desulfidase responsible for tRNA 4-thiouridine de-modification. (2024)
- Preparation of a 4'-Thiouridine Building-Block for Solid-Phase Oligonucleotide Synthesis. (2023)
- Biocatalytic Nucleobase Diversification of 4'-Thionucleosides and Application of Derived 5-Ethynyl-4'-thiouridine for RNA Synthesis Detection. (2024)