Amino-modified Nucleosides
5-[3-[(Trifluoroacetyl)amino]propyl]uridine
Quick view. A uridine nucleoside bearing a three-carbon substituent at pyrimidine C5 terminated by a trifluoroacetamide group. CAS 327623-80-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
![Chemical structure of 5-[3-[(Trifluoroacetyl)amino]propyl]uridine](/structures/fa7c1b3d1600191d.svg)
Product profile
5-[3-[(Trifluoroacetyl)amino]propyl]uridine is classified as c5-propyl uridine bearing a terminal trifluoroacetamide (Formula C14H18F3N3O7; molecular weight 397.30 g/mol).
5-[3-[(Trifluoroacetyl)amino]propyl]uridine provides a reactive functional group for conjugation, immobilization or linker-extension studies.
For 5-[3-[(Trifluoroacetyl)amino]propyl]uridine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Useful catalog search terms
- 327623-80-3
- KLBVGHXBEIVUST-TURQNECASA-N
Physicochemical data
| PubChem CID | 163320925 |
|---|---|
| IUPAC name | N-[3-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]propyl]-2,2,2-trifluoroacetamide |
| InChIKey | KLBVGHXBEIVUST-TURQNECASA-N |
| InChI | InChI=1S/C14H18F3N3O7/c15-14(16,17)12(25)18-3-1-2-6-4-20(13(26)19-10(6)24)11-9(23)8(22)7(5-21)27-11/h4,7-9,11,21-23H,1-3,5H2,(H,18,25)(H,19,24,26)/t7-,8-,9-,11-/m1/s1 |
| SMILES | C1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)CCCNC(=O)C(F)(F)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-[3-[(Trifluoroacetyl)amino]propyl]uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
3'-NH₂-ddA
Amino-modified Nucleosides · CAS: 7403-25-0
BX-MN-00073'-NH₂-ddC
Amino-modified Nucleosides · CAS: 84472-90-2
BX-MN-00083'-NH₂-ddG
Amino-modified Nucleosides · CAS: 66323-49-7
BX-MN-01762-Aminoadenosine
Amino-modified Nucleosides · CAS: 2096-10-8
BX-AMN-01343'-beta-Azido-2',3'-dideoxyuridine
Amino-modified Nucleosides · CAS: 101039-96-7
BX-AMN-00072-Amino-2',3'-dideoxyadenosine
Amino-modified Nucleosides · CAS: 107550-73-2
Frequently asked questions
Can the package size for 5-[3-[(Trifluoroacetyl)amino]propyl]uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0204 and CAS 327623-80-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.