Amino-modified Nucleosides
5-[3-[(Trifluoroacetyl)amino]propyl]uridine
Quick view. We supply 5-[3-[(Trifluoroacetyl)amino]propyl]uridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 327623-80-3. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
5-[3-[(Trifluoroacetyl)amino]propyl]uridine is classified as nucleoside or protected nucleoside intermediate (Formula C14H18F3N3O7; molecular weight 397.304).
5-[3-[(Trifluoroacetyl)amino]propyl]uridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5-[3-[(Trifluoroacetyl)amino]propyl]uridine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- Uridine, 5-[3-[(trifluoroacetyl)amino]propyl]- (9CI)
Useful catalog search terms
- CAS 327623-80-3
- Nucleoside or protected nucleoside intermediate
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | amine functionality |
|---|---|
| Melting point | 176 °C |
| Density | 1.569±0.06 g/cm3(Predicted) |
| pKa | 9.41±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-[3-[(Trifluoroacetyl)amino]propyl]uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-[3-[(Trifluoroacetyl)amino]propyl]uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0204 and CAS 327623-80-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry.