Amino-modified Nucleosides
5-[3-(Trifluoroacetyl)aminopropyn-1-yl]uridine
Quick view. A uridine derivative bearing a C5-linked 3-(trifluoroacetylamino)prop-1-yn-1-yl substituent, CAS 120609-05-4. CAS 120609-05-4. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
![Chemical structure of 5-[3-(Trifluoroacetyl)aminopropyn-1-yl]uridine](/structures/ad5ff960f1c142a6.svg)
Product profile
5-[3-(Trifluoroacetyl)aminopropyn-1-yl]uridine is classified as amino-modified nucleosides (Formula C14H14F3N3O7; molecular weight 393.27).
5-[3-(Trifluoroacetyl)aminopropyn-1-yl]uridine provides a reactive functional group for conjugation, immobilization or linker-extension studies.
For 5-[3-(Trifluoroacetyl)aminopropyn-1-yl]uridine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 5-[3-[(2,2,2-Trifluoroacetyl)amino]-1-propyn-1-yl]uridine
- 5-(3-Trifluoroacetamidopropyn-1-yl)uridine
Useful catalog search terms
- CAS 120609-05-4
- PubChem CID 14768551
Physicochemical data
| PubChem CID | 14768551 |
|---|---|
| SMILES | C1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C#CCNC(=O)C(F)(F)F |
| Systematic name | N-[3-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-ynyl]-2,2,2-trifluoroacetamide |
| Side chain | C5-linked 3-(trifluoroacetylamino)prop-1-yn-1-yl |
| Sugar state | beta-D-ribofuranose |
| Hydroxyl state | 2', 3', and 5' hydroxyl groups unprotected |
| InChIKey | CYFPGTPDBOIBGX-TURQNECASA-N |
| InChI | InChI=1S/C14H14F3N3O7/c15-14(16,17)12(25)18-3-1-2-6-4-20(13(26)19-10(6)24)11-9(23)8(22)7(5-21)27-11/h4,7-9,11,21-23H,3,5H2,(H,18,25)(H,19,24,26)/t7-,8-,9-,11-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-[3-(Trifluoroacetyl)aminopropyn-1-yl]uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-[3-(Trifluoroacetyl)aminopropyn-1-yl]uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0138 and CAS 120609-05-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.