Amino-modified Nucleosides
5'-Amino-2',5'-dideoxyuridine
Quick view. We supply 5'-Amino-2',5'-dideoxyuridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 35959-38-7. Catalog target purity: Specification on request.
Product profile
5'-Amino-2',5'-dideoxyuridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H13N3O4; molecular weight 227.22 g/mol (calculated from molecular formula)).
5'-Amino-2',5'-dideoxyuridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-Amino-2',5'-dideoxyuridine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- Uridine, 5'-amino-2',5'-dideoxy-
Useful catalog search terms
- CAS 35959-38-7
- Nucleoside or protected nucleoside intermediate
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | amine functionality |
|---|---|
| InChI | InChI=1S/C9H13N3O4/c10-4-6-5(13)3-8(16-6)12-2-1-7(14)11-9(12)15/h1-2,5-6,8,13H,3-4,10H2,(H,11,14,15)/t5-,6+,8+/m0/s |
| InChIKey | ABYZQSMQSHNEMQ-SHYZEUOFSA-N |
| SMILES | NC[C@H]1O[C@@H](n2ccc(O)nc2=O)C[C@@H]1O |
| Density | 1.466±0.06 g/cm3(Predicted) |
| pKa | 9.39±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 5'-Amino-2',5'-dideoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-Amino-2',5'-dideoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0074 and CAS 35959-38-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry.