Amino-modified Nucleosides
5-(Azidomethyl)uridine
Quick view. Uridine nucleoside bearing an azidomethyl substituent at the 5-position of the uracil base. CAS 24751-67-5. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5-(Azidomethyl)uridine is classified as amino-modified nucleosides (Formula C10H13N5O6; molecular weight 299.24 g/mol).
5-(Azidomethyl)uridine — Reported as 5-AmU in a study using engineered UCK2 to enable incorporation into cellular RNA.
For 5-(Azidomethyl)uridine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 5-AmU
Useful catalog search terms
- 24751-67-5
- PMID 30735369
- DOI 10.1021/jacs.8b11449
Physicochemical data
| PubChem CID | 121487445 |
|---|---|
| Systematic name | 5-(azidomethyl)-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| Chemical form | Neutral uridine nucleoside with a C5 azidomethyl substituent |
| Stereochemical scope | Ribose stereocenters encoded as (2R,3R,4S,5R) |
| InChIKey | ZAFBFGDCEFQDFD-JXOAFFINSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 5-(Azidomethyl)uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-(Azidomethyl)uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0192 and CAS 24751-67-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not a BX Lab lot specification or product-performance claim.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact BX Lab product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.