Modified Nucleotides
5-[(benzylamino) carbonyl] 2'-O-methyl-uridine-5'-triphosphate, tris salt
Quick view. We supply 5-[(benzylamino) carbonyl] 2'-O-methyl-uridine-5'-triphosphate, tris salt as a 2'-O-methyl nucleotide used to prepare or evaluate modified RNA with improved nuclease resistance and altered immune recognition. A public CAS number is not assigned for this exact form. Catalog target purity: Specification on request.
Structure confirmation
This item requires structure confirmation before quotation. Send the target structure, CAS number, SMILES, InChI or drawing for our technical review.
Canonical name plus a structure drawing, SMILES, InChI or unambiguous CAS number.
Protecting groups, stereochemistry, salt or counterion, hydration and requested form.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
5-[(benzylamino) carbonyl] 2'-O-methyl-uridine-5'-triphosphate, tris salt is classified as nucleotide or nucleotide analog.
5-[(benzylamino) carbonyl] 2'-O-methyl-uridine-5'-triphosphate, tris salt can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
For 5-[(benzylamino) carbonyl] 2'-O-methyl-uridine-5'-triphosphate, tris salt, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Useful catalog search terms
- Nucleotide or nucleotide analog
- 2'-O-methyl modification
- amine functionality
- triphosphate group
- Modified Nucleotides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification; amine functionality; triphosphate group |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5-[(benzylamino) carbonyl] 2'-O-methyl-uridine-5'-triphosphate, tris salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-[(benzylamino) carbonyl] 2'-O-methyl-uridine-5'-triphosphate, tris salt be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MODN-0174, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleotides product family and its named chemistry.