2'-O-Me Nucleosides
5-Benzylaminocarbonyl-2'-O-methyl-5'-O-DMTr-uridine
Quick view. A 2'-O-methyluridine derivative bearing 5'-O-DMTr protection, a free 3'-hydroxyl, and a benzylaminocarbonyl substituent at uracil C5, CAS 1374692-38-2. CAS 1374692-38-2. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5-Benzylaminocarbonyl-2'-O-methyl-5'-O-DMTr-uridine is classified as 2'-o-me nucleosides (Formula C39H39N3O9; molecular weight 693.74).
5-Benzylaminocarbonyl-2'-O-methyl-5'-O-DMTr-uridine provides a reactive functional group for conjugation, immobilization or linker-extension studies.
For 5-Benzylaminocarbonyl-2'-O-methyl-5'-O-DMTr-uridine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 5-Benzylaminocarbonyl-5'-O-DMT-2'-O-methyluridine
- 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-5-[[(phenylmethyl)amino]carbonyl]uridine
Useful catalog search terms
- CAS 1374692-38-2
- MFCD22666312
Physicochemical data
| MDL | MFCD22666312 |
|---|---|
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C(=O)NCC3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O |
| Sugar modification | 2'-O-methyl |
| 5'-hydroxyl protection | DMTr |
| 3'-hydroxyl | Free |
| Base substitution | C5 benzylaminocarbonyl |
| PubChem CID | 127258199 |
| InChIKey | HPIQKEYFNJHHIH-TUDCZORBSA-N |
| InChI | InChI=1S/C39H39N3O9/c1-47-29-18-14-27(15-19-29)39(26-12-8-5-9-13-26,28-16-20-30(48-2)21-17-28)50-24-32-33(43)34(49-3)37(51-32)42-23-31(36(45)41-38(42)46)35(44)40-22-25-10-6-4-7-11-25/h4-21,23,32-34,37,43H,22,24H2,1-3H3,(H,40,44)(H,41,45,46)/t32-,33-,34-,37-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5-Benzylaminocarbonyl-2'-O-methyl-5'-O-DMTr-uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Benzylaminocarbonyl-2'-O-methyl-5'-O-DMTr-uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0017 and CAS 1374692-38-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.