2'-O-Me Nucleosides
5-(Benzylcarbamoyl)-3'-O-acetyl-2'-O-methyl-5'-O-DMTr-uridine
Quick view. Protected 2'-O-methyluridine derivative bearing a 5-(benzylcarbamoyl) substituent, a 3'-O-acetyl group, and a 5'-O-DMTr group. CAS 2095417-22-2. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5-(Benzylcarbamoyl)-3'-O-acetyl-2'-O-methyl-5'-O-DMTr-uridine is classified as 2'-o-me nucleosides (Formula C41H41N3O10; molecular weight 735.79 g/mol).
5-(Benzylcarbamoyl)-3'-O-acetyl-2'-O-methyl-5'-O-DMTr-uridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5-(Benzylcarbamoyl)-3'-O-acetyl-2'-O-methyl-5'-O-DMTr-uridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- 2095417-22-2
Physicochemical data
| Nucleoside scaffold | Uridine |
|---|---|
| Base modification | 5-(benzylcarbamoyl) |
| 2' modification | O-methyl |
| 3' protection | O-acetyl |
| 5' protection | DMTr |
| InChIKey | XGZQNQANWBTCKF-LZURGKRNSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5-(Benzylcarbamoyl)-3'-O-acetyl-2'-O-methyl-5'-O-DMTr-uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-(Benzylcarbamoyl)-3'-O-acetyl-2'-O-methyl-5'-O-DMTr-uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0044 and CAS 2095417-22-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.