Halogenated Nucleosides
5-Chloro-2',3'-dideoxy-3'-fluorouridine
Quick view. 5-Chloro-2',3'-dideoxy-3'-fluorouridine is a halogenated dideoxynucleoside with CAS 119644-22-3. CAS 119644-22-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5-Chloro-2',3'-dideoxy-3'-fluorouridine is classified as halogenated nucleosides (Formula C9H10ClFN2O4; molecular weight 264.64).
5-Chloro-2',3'-dideoxy-3'-fluorouridine can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 5-Chloro-2',3'-dideoxy-3'-fluorouridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- Raluridine
- PubChem CID 451480
- Wikidata Q27272384
Useful catalog search terms
- CAS 119644-22-3
Physicochemical data
| InChIKey | WKVDSZYIGHLONN-RRKCRQDMSA-N |
|---|---|
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)Cl)CO)F |
| Systematic name | 5-chloro-1-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| Structural feature | 5-chloro base with a 2',3'-dideoxy-3'-fluoro sugar |
| InChI | InChI=1S/C9H10ClFN2O4/c10-4-2-13(9(16)12-8(4)15)7-1-5(11)6(3-14)17-7/h2,5-7,14H,1,3H2,(H,12,15,16)/t5-,6+,7+/m0/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Chloro-2',3'-dideoxy-3'-fluorouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Chloro-2',3'-dideoxy-3'-fluorouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0160 and CAS 119644-22-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.