Halogenated Nucleosides
5'-Chloro-5'-deoxyadenosine
Quick view. We supply 5'-Chloro-5'-deoxyadenosine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 892-48-8. Catalog target purity: ≥95%.
Product profile
5'-Chloro-5'-deoxyadenosine is classified as nucleoside or protected nucleoside intermediate (Formula C10H12ClN5O3; molecular weight 285.69).
5'-Chloro-5'-deoxyadenosine — 5''-Deoxy-5''-chloroadenosine is an intermediate in the synthesis of 5''-Deoxy-5''-(methylthio)adenosine, a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways.
For 5'-Chloro-5'-deoxyadenosine, reported solubility: DMSO (Slightly), Water (Slightly, Heated). Storage: Keep in dark place,Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 5'-Cl-5'-deoxyadenosine
- 5'-Deoxy-5'-chloroadenosine
- 5’-chloro-5’-deoxy-adenosin
- Adenosine,5'-chloro-5'-deoxy-
- 5'-CHLORO-5'-DEOXY-D-ADENOSINE
- 5-CHLORO-5-DEOXYADENOSINE HYDRATE
- 5'-CHLORO-5'-DEOXYADENOSINE
- 5'-CHLORO-5'-DEOXYADENOSINE USP/EP/BP
Useful catalog search terms
- CAS 892-48-8
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| SMILES | O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3CCl |
|---|---|
| InChI | InChI=1S/C10H12ClN5O3/c11-1-4-6(17)7(18)10(19-4)16-3-15-5-8(12)13-2-14-9(5)16/h2-4,6-7,10,17-18H,1H2,(H2,12,13,14)/t4-,6-,7-,10-/m1/s |
| InChIKey | IYSNPOMTKFZDHZ-KQYNXXCUSA-N |
| Melting point | 187 °C (exothermic decomp onset @144.5 C)(lit.) |
| Boiling point | 645.6±65.0 °C(Predicted) |
| Density | 2.03±0.1 g/cm3(Predicted) |
| pKa | 13.03±0.70(Predicted) |
| Form | Solid |
| Color | Off-White to Light Beige |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-Chloro-5'-deoxyadenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 5'-Chloro-5'-deoxyadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0117 and CAS 892-48-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.