Halogenated Nucleosides
5-Fluorocytidine
Quick view. We supply 5-Fluorocytidine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 2341-22-2. Catalog target purity: Specification on request.
Product profile
5-Fluorocytidine is classified as nucleoside or protected nucleoside intermediate (Formula C9H12FN3O5; molecular weight 261.21).
5-Fluorocytidine — 5-Fluoropyrimidine nucleotides as probes of RNA structure using 19F-NMR spectroscopy
For 5-Fluorocytidine, reported solubility: Methanol (Slightly, Heated), Water (Slightly). Storage: Keep in dark place,Inert atmosphere,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 5-fluoro-cytidin
- 5-Fluoro-D-cytidine
Useful catalog search terms
- CAS 2341-22-2
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H12FN3O5/c10-3-1-13(9(17)12-7(3)11)8-6(16)5(15)4(2-14)18-8/h,4-6,8,14-16H,2H2,(H2,11,12,17)/t4-,5-,6-,8-/m1/s |
|---|---|
| InChIKey | STRZQWQNZQMHQR-UAKXSSHOSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=C(F)C(N)=NC2=O)[C@H](O)[C@@H]1O |
| Melting point | 196-200 °C (lit.) |
| Boiling point | 511.4±60.0 °C(Predicted) |
| Density | 1.98±0.1 g/cm3(Predicted) |
| pKa | 13.48±0.70(Predicted) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5-Fluorocytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Fluorocytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Fluorocytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0200 and CAS 2341-22-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.