Modified Nucleosides
5-formyl-2'-deoxyuridine
Quick view. We supply 5-formyl-2'-deoxyuridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 4494-26-2. Catalog target purity: Specification on request.
Product profile
5-formyl-2'-deoxyuridine is classified as nucleoside or protected nucleoside intermediate (Formula C10H12N2O6; molecular weight 256.21).
5-formyl-2'-deoxyuridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5-formyl-2'-deoxyuridine, reported solubility: DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly, Sonicated). Storage: under inert gas (nitrogen or Argon) at 2-8°C.
Names and search terms
Confirmed or normalized name variants
- 1-(2-Deoxypentofuranosyl)-4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carbaldehyde
- 5-Formyl-dU
- 5-formyl-2'-dU
- α-Oxothymidine
- Thymidine, α-oxo-
- 2'-deoxy-5-forMyluridine
- 1-(2-Deoxy-β-D-ribofuranosyl)-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinecarbaldehyde
- 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidine-5-carbaldehyde
Useful catalog search terms
- CAS 4494-26-2
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C10H12N2O6/c13-3-5-2-12(10(17)11-9(5)16)8-1-6(15)7(4-14)18-8/h2-3,6-8,14-15H,1,4H2,(H,11,16,17) |
|---|---|
| InChIKey | MVORBLZUGBSUNB-UHFFFAOYSA-N |
| SMILES | O=Cc1cn(C2CC(O)C(CO)O2)c(=O)nc1O |
| Melting point | 162 - 164°C |
| Density | 1.670±0.06 g/cm3(Predicted) |
| pKa | 8.23±0.10(Predicted) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5-Formyl-2'-deoxyuridine is a product formed when the 5-methyl group of thymine in DNA undergoes oxidation due to exposure to gamma radiation or certain chemical agents. Serving as a biomarker of oxidative DNA damage, 5-formyl-2'-deoxyuridine is employed in investigations of DNA damage and repair mechanisms. Additionally, 5-Formyl-2'-deoxyuridine can be used in studies involving chemically crosslinking with peptides derived from the RecA protein.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 5-formyl-2'-deoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0545 and CAS 4494-26-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.