Modified Nucleosides
5-Hydroxymethyl uridine
Quick view. We supply 5-Hydroxymethyl uridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 30414-00-7. Catalog target purity: Specification on request.
Product profile
5-Hydroxymethyl uridine is classified as nucleoside or protected nucleoside intermediate (Formula C10H14N2O7; molecular weight 274.23).
5-Hydroxymethyl uridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5-Hydroxymethyl uridine, form: Solid.
Names and search terms
Confirmed or normalized name variants
- 5-Hydroxymethyl-Ur
- Uridine, 5-(hydroxymethyl)-
Useful catalog search terms
- CAS 30414-00-7
- Nucleoside or protected nucleoside intermediate
- fluorescent label
- Modified Nucleosides
Physicochemical data
| Key chemistry motifs | fluorescent label |
|---|---|
| InChI | InChI=1S/C10H14N2O7/c13-2-4-1-12(10(18)11-8(4)17)9-7(16)6(15)5(3-14)19-9/h,5-7,9,13-16H,2-3H2,(H,11,17,18)/t5-,6-,7-,9-/m1/s |
| InChIKey | VQAJJNQKTRZJIQ-JXOAFFINSA-N |
| SMILES | C1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)CO |
| Melting point | 167-168 °C |
| Density | 1.689±0.06 g/cm3(Predicted) |
| pKa | 9.01±0.10(Predicted) |
| Form | Solid |
| Color | White to light yellow |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5-Hydroxymethyl uridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Fluorescent labels enable non-radioactive detection and can reduce downstream staining or secondary-label steps.
Method limitations
- Dye-labeled nucleotides or amidites are bulkier than native monomers; incorporation efficiency, label density, photobleaching and light exposure should be controlled.
These points describe 5-Hydroxymethyl uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Hydroxymethyl uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0476 and CAS 30414-00-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5-Hydroxymethyl uridine or the named structural feature represented by this product.