Halogenated Nucleosides
5-Iodo-2',3'-dideoxycytidine
Quick view. We supply 5-Iodo-2',3'-dideoxycytidine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 114748-57-1. Catalog target purity: Specification on request.
Product profile
5-Iodo-2',3'-dideoxycytidine is classified as nucleoside or protected nucleoside intermediate (Formula C9H12IN3O3; molecular weight 337.11).
5-Iodo-2',3'-dideoxycytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5-Iodo-2',3'-dideoxycytidine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- 1-(2,3-Dideoxy-3-iodopentofuranosyl)-4-imino-1,4-dihydropyrimidin-2-ol
- 5-I-ddC
- 2',3'-Dideoxy-5-iodocytidine
- 5-Iodo-2',3'-Dideoxy-D-Cytidine
- Cytidine, 2',3'-dideoxy-5-iodo-
- 5-Iodo-2’,3’-dideoxycytidine,, IddC
Useful catalog search terms
- CAS 114748-57-1
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H12IN3O3/c10-5-3-8(16-6(5)4-14)13-2-1-7(11)12-9(13)15/h1-2,5-6,8,14H,3-4H2,(H2,11,12,15)/t5-,6+,8+/m0/s |
|---|---|
| InChIKey | UOPKTRLAQRTEKJ-SHYZEUOFSA-N |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)N)CO)I |
| Boiling point | 448.2±55.0 °C(Predicted) |
| Density | 2.22±0.1 g/cm3(Predicted) |
| pKa | 14.44±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 5-Iodo-2',3'-dideoxycytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2'-5-CF3-dU
Halogenated Nucleosides · CAS: 70-00-8
BX-HN-00026-Cl-purine-2'-deoxyriboside
Halogenated Nucleosides · CAS: 4594-45-0
BX-HN-00038-Cl-2'-dA
Halogenated Nucleosides · CAS: 85562-55-6
BX-HN-00042'-Chloro-2'-deoxycytidine
Halogenated Nucleosides · CAS: 10212-19-8
BX-HN-00055-bromo-2'-deoxycytidine
Halogenated Nucleosides · CAS: 1022-79-3
BX-HN-00065-Iodouridine
Halogenated Nucleosides · CAS: 1024-99-3
Frequently asked questions
Can the package size for 5-Iodo-2',3'-dideoxycytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0014 and CAS 114748-57-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.