Halogenated Nucleosides
5-Iodo-2',3'-dideoxyuridine
Quick view. We supply 5-Iodo-2',3'-dideoxyuridine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 105784-83-6. Catalog target purity: Specification on request.
Product profile
5-Iodo-2',3'-dideoxyuridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H11IN2O4; molecular weight 338.1).
5-Iodo-2',3'-dideoxyuridine — 2′,3′-Dideoxy-5-iodouridine (5-Iodo-2′,3′-dideoxyuridine) was used in preparation of fluorescence-tagged chain-terminating reagents, T-526, for rapid DNA sequencing.
For 5-Iodo-2',3'-dideoxyuridine, storage: 2-8°C. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- Uridine, 2',3'-dideoxy-5-iodo-
- 5-I-ddU
- 2',3'-DIDEOXY-5-IODOURIDINE
- 5-Iodo-2',3'-Dideoxy-D-Uridine
- 5-Iodo-2’,3’-dideoxyuridine,, IddU
- 5-IODO-2',3'-DIDEOXYURIDINE USP/EP/BP
- 1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-iododihydropyrimidine-2,4(1H,3H)-dione
- 1-((2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione
Useful catalog search terms
- CAS 105784-83-6
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H11IN2O4/c10-6-3-12(9(15)11-8(6)14)7-2-1-5(4-13)16-7/h,5,7,13H,1-2,4H2,(H,11,14,15)/t5-,7+/m0/s |
|---|---|
| InChIKey | OBGFSDPYSQAECJ-CAHLUQPWSA-N |
| SMILES | C1C[C@@H](O[C@@H]1CO)N2C=C(C(=O)NC2=O)I |
| Melting point | 176 °C (dec.)(lit.) |
| Density | 2.02±0.1 g/cm3(Predicted) |
| pKa | 7.94±0.10(Predicted) |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5-Iodo-2',3'-dideoxyuridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 5-Iodo-2',3'-dideoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Iodo-2',3'-dideoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0009 and CAS 105784-83-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.