Nucleosides & Deoxynucleosides
5-Me-2'-dC
Quick view. 5-Me-2'-dC (5-methyl-2'-deoxycytidine) is an epigenetic DNA nucleoside standard and synthetic intermediate. CAS 838-07-3. Catalog target purity: Specification on request.
Product profile
5-Me-2'-dC is classified as nucleoside or protected nucleoside intermediate (Formula C10H15N3O4; molecular weight 241.24).
5-Me-2'-dC — 5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo DNA methylation. It has been used in epigenetics research to investigate the dynamics of DNA methylation pattern in the control of gene expression.
For 5-Me-2'-dC, reported solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly). Storage: −20°C.
Names and search terms
Confirmed or normalized name variants
- 2'-DEOXY-5-METHYLCYTIDINE
- 4-AMINO-1-[(2R,4S,5R)-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-5-METHYL-PYRIMIDIN-2-ONE
- 5-METHYL-2'-DEOXYCYTIDINE
- 5-METHYL-2'-DEXOYCYTIDINE
- 5-METHYL-DC
- 2’-deoxy-5-methyl-cytidin
- 5-methyldeoxycytidine
- Cytidine, 2'-deoxy-5-methyl-
Useful catalog search terms
- CAS 838-07-3
- Nucleoside or protected nucleoside intermediate
- Nucleosides & Deoxynucleosides
Physicochemical data
| Melting point | 217-219 °C(lit.) |
|---|---|
| Boiling point | 492.8±55.0 °C(Predicted) |
| pKa | pK1:4.33 (25°C) |
| Form | Powder |
| Color | White to Off-white |
| SMILES | OC[C@H]1O[C@@H](N2C=C(C)C(N)=NC2=O)C[C@@H]1O |
| InChI | InChI=1S/C10H15N3O4/c1-5-3-13(10(16)12-9(5)11)8-2-6(15)7(4-14)17-8/h,6-8,14-15H,2,4H2,1H3,(H2,11,12,16)/t6-,7+,8+/m0/s |
| InChIKey | LUCHPKXVUGJYGU-XLPZGREQSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5-Me-2'-dC can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 5-Me-2'-dC be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-NDO-0012 and CAS 838-07-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Nucleosides & Deoxynucleosides product family and its named chemistry.