Amino-modified Nucleosides
5-[(N-Methyl-N-trifluoroacetyl)aminomethyl]uridine
Quick view. A protected 5-aminomethyluridine building block for structure-specific modified-nucleoside synthesis research. CAS 163496-07-9. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
![Chemical structure of 5-[(N-Methyl-N-trifluoroacetyl)aminomethyl]uridine](/structures/52480355b20b1755.svg)
Product profile
5-[(N-Methyl-N-trifluoroacetyl)aminomethyl]uridine is classified as amino-modified nucleosides (Formula C13H16F3N3O7; molecular weight 383.28).
5-[(N-Methyl-N-trifluoroacetyl)aminomethyl]uridine — Protected 5-aminomethyluridine building block for structure-specific modified-nucleoside synthesis research.
For 5-[(N-Methyl-N-trifluoroacetyl)aminomethyl]uridine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 5-N-TFA-N-methylaminomethyluridine
- Uridine, 5-[[methyl(2,2,2-trifluoroacetyl)amino]methyl]-
Useful catalog search terms
- CAS 163496-07-9
- N-methyl N-trifluoroacetyl aminomethyl uridine
Physicochemical data
| Nucleoside modification | 5-aminomethyl |
|---|---|
| Amino substituents | N-methyl; N-trifluoroacetyl |
| PubChem CID | 168447751 |
| InChI | InChI=1S/C13H16F3N3O7/c1-18(11(24)13(14,15)16)2-5-3-19(12(25)17-9(5)23)10-8(22)7(21)6(4-20)26-10/h3,6-8,10,20-22H,2,4H2,1H3,(H,17,23,25)/t6-,7-,8-,10-/m1/s1 |
| InChIKey | CMGFNSOQJGRGFE-FDDDBJFASA-N |
| SMILES | CN(Cc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]c1=O)C(=O)C(F)(F)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-[(N-Methyl-N-trifluoroacetyl)aminomethyl]uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-[(N-Methyl-N-trifluoroacetyl)aminomethyl]uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0148 and CAS 163496-07-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.