Amino-modified Nucleosides
5-[N-(tert-Butoxycarbonylmethyl)-N-(trifluoroacetyl)aminomethyl]-2',3'-O-isopropylidene-2-thiouridine
Quick view. A multiply protected, C5 amino-functionalized 2-thiouridine intermediate identified by CAS 89129-10-2. CAS 89129-10-2. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
![Chemical structure of 5-[N-(tert-Butoxycarbonylmethyl)-N-(trifluoroacetyl)aminomethyl]-2',3'-O-isopropylidene-2-thiouridine](/structures/c370576cceec7be8.svg)
Product profile
5-[N-(tert-Butoxycarbonylmethyl)-N-(trifluoroacetyl)aminomethyl]-2',3'-O-isopropylidene-2-thiouridine is classified as amino-modified nucleosides (Formula C21H28F3N3O8S; molecular weight 539.52).
5-[N-(tert-Butoxycarbonylmethyl)-N-(trifluoroacetyl)aminomethyl]-2',3'-O-isopropylidene-2-thiouridine — Multiply protected amino-functionalized 2-thiouridine intermediate for further nucleoside chemistry
For 5-[N-(tert-Butoxycarbonylmethyl)-N-(trifluoroacetyl)aminomethyl]-2',3'-O-isopropylidene-2-thiouridine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 5-(N-t-Butyloxycarbonylmethyl)-N-(trifluoroacetyl) aminomethyl)-2-thiouridine
- beta-D-Ribofuranose analogue 1
Useful catalog search terms
- CAS 89129-10-2
- CB44672456
Physicochemical data
| Nucleoside scaffold | 2-Thiouridine |
|---|---|
| Ribose protection | 2',3'-O-isopropylidene |
| C5 substituent | N-(tert-butoxycarbonylmethyl)-N-(trifluoroacetyl)aminomethyl |
| Ester protection | tert-Butyl ester |
| Free hydroxyl | 5' hydroxymethyl |
| PubChem CID | 168447929 |
| InChI | InChI=1S/C21H28F3N3O8S/c1-19(2,3)33-12(29)8-26(17(31)21(22,23)24)6-10-7-27(18(36)25-15(10)30)16-14-13(11(9-28)32-16)34-20(4,5)35-14/h7,11,13-14,16,28H,6,8-9H2,1-5H3,(H,25,30,36)/t11-,13-,14-,16-/m1/s1 |
| InChIKey | DRDPZVPTYQHFTB-XKVFNRALSA-N |
| SMILES | CC1(O[C@@H]2[C@H](O[C@H]([C@@H]2O1)N3C=C(C(=O)NC3=S)CN(CC(=O)OC(C)(C)C)C(=O)C(F)(F)F)CO)C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-[N-(tert-Butoxycarbonylmethyl)-N-(trifluoroacetyl)aminomethyl]-2',3'-O-isopropylidene-2-thiouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-[N-(tert-Butoxycarbonylmethyl)-N-(trifluoroacetyl)aminomethyl]-2',3'-O-isopropylidene-2-thiouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0241 and CAS 89129-10-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.