Protected Nucleosides
5'-O-(4,4'-Dimethoxytrityl)-3'-O-(2-methoxyethyl)-5-methyluridine
Quick view. 5-methyluridine derivative bearing 5'-O-dimethoxytrityl protection, a 3'-O-(2-methoxyethyl) substituent and a free 2'-hydroxyl group. CAS 256223-94-6. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-(4,4'-Dimethoxytrityl)-3'-O-(2-methoxyethyl)-5-methyluridine is classified as protected nucleosides (Formula C34H38N2O9; molecular weight 618.68 g/mol).
5'-O-(4,4'-Dimethoxytrityl)-3'-O-(2-methoxyethyl)-5-methyluridine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 5'-O-(4,4'-Dimethoxytrityl)-3'-O-(2-methoxyethyl)-5-methyluridine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-3'-O-(2-methoxyethyl)-5-methyluridine
Useful catalog search terms
- 256223-94-6
Physicochemical data
| Systematic name | 1-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-hydroxy-4-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dione |
|---|---|
| Chemical form | Neutral 5'-O-DMTr-protected, 3'-O-MOE-modified 5-methyluridine |
| Structural scope | 5'-O-DMTr and 3'-O-(2-methoxyethyl) substitution with a free 2'-hydroxyl |
| Stereochemical scope | Four defined ribose stereocenters |
| InChIKey | AYZFIFVZDMZCGU-PBAMLIMUSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-O-(4,4'-Dimethoxytrityl)-3'-O-(2-methoxyethyl)-5-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-(4,4'-Dimethoxytrityl)-3'-O-(2-methoxyethyl)-5-methyluridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0362 and CAS 256223-94-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.