2'-O-Me Nucleosides
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-2-thiouridine
Quick view. A stereodefined 2'-O-methyl-2-thiouridine derivative bearing 5'-O-DMTr protection and a free 3'-hydroxyl, CAS 302918-83-8. CAS 302918-83-8. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-2-thiouridine is classified as 2'-o-me nucleosides (Formula C31H32N2O7S; molecular weight 576.70 g/mol).
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-2-thiouridine — 5'-O-DMTr-protected 2'-O-methyl-2-thiouridine building block for modified nucleoside chemistry.
For 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-2-thiouridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- 302918-83-8
- PubChem CID 12043012
- KWAXQCAGJXIZKB-YXINZVNLSA-N
- 5'-O-DMTr 2'-O-methyl-2-thiouridine
Physicochemical data
| PubChem CID | 12043012 |
|---|---|
| IUPAC name | 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-2-sulfanylidenepyrimidin-4-one |
| InChIKey | KWAXQCAGJXIZKB-YXINZVNLSA-N |
| InChI | InChI=1S/C31H32N2O7S/c1-36-23-13-9-21(10-14-23)31(20-7-5-4-6-8-20,22-11-15-24(37-2)16-12-22)39-19-25-27(35)28(38-3)29(40-25)33-18-17-26(34)32-30(33)41/h4-18,25,27-29,35H,19H2,1-3H3,(H,32,34,41)/t25-,27-,28-,29-/m1/s1 |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=S)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O |
| Stereochemistry | (2R,3R,4R,5R) nucleoside sugar |
| Protecting group | 5'-O-(4,4'-dimethoxytrityl) |
| Nucleoside modifications | 2'-O-methyl; 2-thio |
| Free hydroxyl | 3'-OH |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Reference compound for chemical identity studies involving protected 2'-O-methyl-2-thiouridine.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-2-thiouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-2-thiouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0084 and CAS 302918-83-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.