Protected Nucleosides
5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydrouridine
Quick view. A 5'-O-acetyl-protected uridine analogue with a C2'-C3' double bond and no 2'- or 3'-hydroxyl groups, CAS 42867-74-3. CAS 42867-74-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydrouridine is classified as 5'-o-acetyl-protected didehydro-dideoxy pyrimidine nucleoside (Formula C11H12N2O5; molecular weight 252.22 g/mol).
5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydrouridine — A 5'-O-acetyl-protected unsaturated uridine intermediate for dideoxynucleoside synthesis research.
For 5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydrouridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- 5'-O-Acetyl-2',3'-didehydro-2',3'-dideoxyuridine
- 5'-O-Acetyl-d4U
- SCHEMBL1879258
Useful catalog search terms
- 42867-74-3
- C11H12N2O5
- ZJEYZGAQPYLRFC-WCBMZHEXSA-N
Physicochemical data
| InChIKey | ZJEYZGAQPYLRFC-WCBMZHEXSA-N |
|---|---|
| Nucleobase | Uracil |
| Protecting group | 5'-O-acetyl |
| Sugar modification | 2',3'-dideoxy with a C2'-C3' double bond |
| InChI | InChI=1S/C11H12N2O5/c1-7(14)17-6-8-2-3-10(18-8)13-5-4-9(15)12-11(13)16/h2-5,8,10H,6H2,1H3,(H,12,15,16)/t8-,10+/m0/s1 |
| SMILES | CC(=O)OC[C@@H]1C=C[C@@H](O1)N2C=CC(=O)NC2=O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydrouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydrouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0244 and CAS 42867-74-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not a BX Lab lot specification or product-performance claim.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.