Other Phosphoramidites
5'-O-DMT-2'-O-MOE-rG(iBu)-3'- ((2-cyanoethoxy)(diisopropylamino)phosphoramidite)-ethyl-diisopropylphosphoramidite
Quick view. 5'-O-DMT-2'-O-MOE-rG(iBu)-3'-ethyl-diisopropylphosphoramidite is a guanosine MOE specialty amidite for modified oligonucleotide and backbone/linker chemistry research. It is suited to exploratory ASO monomer libraries where MOE sugar modification and non-standard phosphoramidite architecture are both required. A public CAS number is not assigned for this exact form. Catalog target purity: Specification on request.
Product profile
5'-O-DMT-2'-O-MOE-rG(iBu)-3'- ((2-cyanoethoxy)(diisopropylamino)phosphoramidite)-ethyl-diisopropylphosphoramidite is classified as protected oligonucleotide phosphoramidite building block.
5'-O-DMT-2'-O-MOE-rG(iBu)-3'- ((2-cyanoethoxy)(diisopropylamino)phosphoramidite)-ethyl-diisopropylphosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For 5'-O-DMT-2'-O-MOE-rG(iBu)-3'- ((2-cyanoethoxy)(diisopropylamino)phosphoramidite)-ethyl-diisopropylphosphoramidite, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Useful catalog search terms
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-O-MOE modification
- amine functionality
- phosphoramidite coupling group
- Other Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-MOE modification; amine functionality; phosphoramidite coupling group |
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Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-O-DMT-2'-O-MOE-rG(iBu)-3'- ((2-cyanoethoxy)(diisopropylamino)phosphoramidite)-ethyl-diisopropylphosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-OP-00045'-O-DMT-2'-O-MOE-rT-3'- ((2-cyanoethoxy)(diisopropylamino)phosphoramidite)-ethyl-diisopropylphosphoramidite
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BX-OP-00066-((bis(4-methoxyphenyl)(phenyl)methyl)amino)hexyl (2-cyanoethyl) diisopropylphosphoramidite
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BX-OP-0007Bis(5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy)-diisopropylphosphoramidite
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BX-OP-0008Bis(5'-O-DMTr-2'-O-MOE-rA(Bz)-3'-oxy)-diisopropylphosphoramidite
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Frequently asked questions
Can the package size for 5'-O-DMT-2'-O-MOE-rG(iBu)-3'- ((2-cyanoethoxy)(diisopropylamino)phosphoramidite)-ethyl-diisopropylphosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-OP-0003, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry.