Modified Nucleosides
7,8-Dihydro-8-oxo-7-propargylguanosine
Quick view. An N7-propargyl, 8-oxo modified guanosine nucleoside with a terminal alkyne for CuAAC conjugation workflows. CAS 2763084-98-4. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
7,8-Dihydro-8-oxo-7-propargylguanosine is classified as modified nucleosides (Formula C13H15N5O6; molecular weight 337.29).
7,8-Dihydro-8-oxo-7-propargylguanosine — Its terminal alkyne provides a reactive handle for CuAAC conjugation with azide-bearing partners.
For 7,8-Dihydro-8-oxo-7-propargylguanosine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- Guanosine, 7,8-dihydro-8-oxo-7-(2-propyn-1-yl)-
Useful catalog search terms
- CAS 2763084-98-4
- PubChem CID 175676469
Physicochemical data
| Modification pattern | N7-propargyl and 8-oxo |
|---|---|
| Reactive handle | Terminal alkyne |
| InChIKey | IVYBTWFLNFTLFY-IOSLPCCCSA-N |
| PubChem CID | 175676469 |
| InChI | InChI=1S/C13H15N5O6/c1-2-3-17-6-9(15-12(14)16-10(6)22)18(13(17)23)11-8(21)7(20)5(4-19)24-11/h1,5,7-8,11,19-21H,3-4H2,(H3,14,15,16,22)/t5-,7-,8-,11-/m1/s1 |
| SMILES | C#CCN1C2=C(N=C(NC2=O)N)N(C1=O)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 7,8-Dihydro-8-oxo-7-propargylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 7,8-Dihydro-8-oxo-7-propargylguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0643 and CAS 2763084-98-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact BX Lab product, supplied form, lot specification, availability or performance.
Technology platforms
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