Halogenated Nucleosides
7-Iodo-7-deaza-2'-deoxyadenosine
Quick view. We supply 7-Iodo-7-deaza-2'-deoxyadenosine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 166247-63-8. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
7-Iodo-7-deaza-2'-deoxyadenosine is classified as nucleoside or protected nucleoside intermediate (Formula C11H13IN4O3; molecular weight 376.15).
7-Iodo-7-deaza-2'-deoxyadenosine — 5-Iodo-2’-deoxytubercidin is a derivative of 7-Iodo-7-deazadenine designed to be incorporated into DNA by primers extension by using Vent(exo-) polymerase. Possesses photophysical properties.
For 7-Iodo-7-deaza-2'-deoxyadenosine, reported solubility: DMSO (Slightly), Methanol (Slightly, Heated). Storage: Keep in dark place,Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 7-I-7-Deaza-dA
- 5-Iodo-2'-deoxytubercidin
- 2'-Deoxy-7-iodotubercidin
- 7-DEAZA-7-IODO-2'-DEOXYADENOSINE
- 7-Deaza-7-Iodo-2'-deoxyadeonsine
- 7-DEAZA-7-IODO-2'-DEOXYADENOSINE
- 7-DEAZA-7-IODO-2'-DEOXYADENOSINE USP/EP/BP
- 4-Amino-5-iodo-7-(2-deoxy--D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
Useful catalog search terms
- CAS 166247-63-8
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| Melting point | >206°C (dec.) |
|---|---|
| Boiling point | 657.4±55.0 °C(Predicted) |
| Density | 2.35±0.1 g/cm3(Predicted) |
| pKa | 13.27±0.60(Predicted) |
| Form | Solid |
| Color | White to Off-White |
| SMILES | C1N=C(N)C2C(I)=CN([C@H]3O[C@H](CO)[C@H](C3)O)C=2N=1 |&1:9,11,14,r| |
| InChI | InChI=1/C11H13IN4O3/c12-5-2-16(8-1-6(18)7(3-17)19-8)11-9(5)10(13)14-4-15-11/h,4,6-8,17-18H,1,3H2,(H2,13,14,15)/t6-,7+,8-/s |
| InChIKey | LIIIRHQRQZIIRT-CENUSHNHNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 7-Iodo-7-deaza-2'-deoxyadenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Related products
2'-5-CF3-dU
Halogenated Nucleosides · CAS: 70-00-8
BX-HN-00026-Cl-purine-2'-deoxyriboside
Halogenated Nucleosides · CAS: 4594-45-0
BX-HN-00038-Cl-2'-dA
Halogenated Nucleosides · CAS: 85562-55-6
BX-HN-00042'-Chloro-2'-deoxycytidine
Halogenated Nucleosides · CAS: 10212-19-8
BX-HN-00055-bromo-2'-deoxycytidine
Halogenated Nucleosides · CAS: 1022-79-3
BX-HN-00065-Iodouridine
Halogenated Nucleosides · CAS: 1024-99-3
Frequently asked questions
Can the package size for 7-Iodo-7-deaza-2'-deoxyadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0060 and CAS 166247-63-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 7-Iodo-7-deaza-2'-deoxyadenosine or the named structural feature represented by this product.
- Synthesis of nucleosides and dNTPs bearing oligopyridine ligands linked through an octadiyne tether, their incorporation into DNA and complexation with transition metal cations. (2013)
- Synthesis and photophysical properties of 7-deaza-2'-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7. (2008)
- An efficient method for the construction of functionalized DNA bearing amino acid groups through cross-coupling reactions of nucleoside triphosphates followed by primer extension or PCR. (2007)