Halogenated Nucleosides
8-Chloroadenosine
Quick view. We supply 8-Chloroadenosine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 34408-14-5. Catalog target purity: ≥95%.
Product profile
8-Chloroadenosine is classified as nucleoside or protected nucleoside intermediate (Formula C10H12ClN5O4; molecular weight 301.69).
8-Chloroadenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 8-Chloroadenosine, reported solubility: Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO. Storage: Sealed in dry,Store in freezer, under -20°C.
Names and search terms
Confirmed or normalized name variants
- 8-Cl-rA
- 8-CL-ADO
- NSC354258
- ADENOSINE, 8-CHLORO
- 8-Chloro-D-adenosine
- 8-CHLOROADENOSINE USP/EP/BP
- 6-Amino-8-chloropurine riboside
- 8Chloroadenosine,8 Chloroadenosine
Useful catalog search terms
- CAS 34408-14-5
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| SMILES | C1=NC(=C2C(=N1)N(C(=N2)Cl)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N |
|---|---|
| InChIKey | MHDPPLULTMGBSI-UUOKFMHZSA-N |
| InChI | InChI=1S/C10H12ClN5O4/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,13,14)/t3-,5-,6-,9-/m1/s |
| Melting point | 189-191 °C |
| Boiling point | 707.4±70.0 °C(Predicted) |
| Density | 2.19±0.1 g/cm3(Predicted) |
| pKa | 12.90±0.70(Predicted) |
| Form | Crystalline solid. |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 8-Chloroadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0140 and CAS 34408-14-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.