Modified Nucleosides
8-Mercaptoguanosine
Quick view. A guanosine nucleoside bearing a mercapto/thioxo modification at purine C8, identified by CAS 26001-38-7. CAS 26001-38-7. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
8-Mercaptoguanosine is classified as modified nucleosides (Formula C10H13N5O5S; molecular weight 315.31).
8-Mercaptoguanosine provides a reactive functional group for conjugation, immobilization or linker-extension studies.
For 8-Mercaptoguanosine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 8-Thioguanosine
- 8-SH-Guo
- 8-Mercapto-D-guanosine
- 7,8-Dihydro-8-thioxoguanosine
- Guanosine, 7,8-dihydro-8-thioxo-
Useful catalog search terms
- CAS 26001-38-7
- Alternate CAS 29836-03-1
- PubChem CID 135457302
Physicochemical data
| PubChem CID | 135457302 |
|---|---|
| InChIKey | KZELNMSPWPFAEB-UMMCILCDSA-N |
| Nucleoside scaffold | guanosine |
| Modification | purine C8 mercapto/thioxo |
| Alternate registry identifier | 29836-03-1 |
| InChI | InChI=1S/C10H13N5O5S/c11-9-13-6-3(7(19)14-9)12-10(21)15(6)8-5(18)4(17)2(1-16)20-8/h2,4-5,8,16-18H,1H2,(H,12,21)(H3,11,13,14,19)/t2-,4-,5-,8-/m1/s1 |
| SMILES | C([C@@H]1[C@H]([C@H]([C@@H](O1)N2C3=C(C(=O)NC(=N3)N)NC2=S)O)O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 8-Mercaptoguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
(S)-cEt-rA
Modified Nucleosides · CAS: 1197033-34-3
BX-OP-0069S-Adenosyl-L-methionine (SAM)
Modified Nucleosides · CAS: 485-80-3
BX-MN-01875-(Carboxyhydroxymethyl)uridine
Modified Nucleosides · CAS: 934743-11-0
BX-MN-0719(R)-N6-(2,3-Dihydro-1H-inden-1-yl)adenosine
Modified Nucleosides · CAS: 96392-15-3
BX-MN-01972,2'-Cyclocytidine hydrochloride
Modified Nucleosides · CAS: 10212-25-6
BX-MN-0199N3-Allyluridine
Modified Nucleosides · CAS: 103951-13-9
Frequently asked questions
Can the package size for 8-Mercaptoguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0685 and CAS 26001-38-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.